Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

被引：40

作者：

Fernandes, Rayzel C. ^{[1
,2
]}

Toubia, John ^{[3
,4
]}

Townley, Scott ^{[1
,2
]}

Hanson, Adrienne R. ^{[1
,2
]}

Dredge, B. Kate ^{[4
,5
]}

Pillman, Katherine A. ^{[4
,5
]}

Bert, Andrew G. ^{[4
,5
]}

Winter, Jean M. ^{[1
,2
]}

Iggo, Richard ^{[1
,2
,6
]}

Das, Rajdeep ^{[1
,2
,7
]}

Obinata, Daisuke ^{[8
,9
]}

Sandhu, Shahneen ^{[10
,11
]}

Risbridger, Gail P. ^{[9
,10
,11
]}

Taylor, Renea A. ^{[10
,12
]}

Lawrence, Mitchell G. ^{[9
,10
]}

Butler, Lisa M. ^{[13
,14
]}

Zoubeidi, Amina ^{[15
]}

Gregory, Philip A. ^{[4
,5
,14
]}

Tilley, Wayne D. ^{[1
,2
]}

Hickey, Theresa E. ^{[1
,2
]}

Goodall, Gregory J. ^{[4
,5
,16
]}

Selth, Luke A. ^{[1
,2
,17
]}

机构：

[1] Univ Adelaide, Dame Roma Mitchell Canc Res Labs, Adelaide Med Sch, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide Med Sch, Adelaide, SA 5005, Australia

[3] Ctr Canc Biol, Alliance SA Pathol, ACRF Canc Genom Facil, Frome Rd, Adelaide, SA 5005, Australia

[4] Univ South Australia, Frome Rd, Adelaide, SA 5005, Australia

[5] Ctr Canc Biol, Alliance SA Pathol, Adelaide, SA 5005, Australia

[6] Inst Bergonie Unicanc, INSERM U1218, Bordeaux, France

[7] Northwestern Univ, Transplant Immunol Lab, Comprehens Transplant Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

[8] Nihon Univ, Dept Urol, Sch Med, Tokyo 1738610, Japan

[9] Monash Univ, Dept Anat & Dev Biol, Monash Partners Comprehens Canc Consortium, Monash Biomed Discovery Inst,Prostate Canc Res Gr, Clayton, Vic 3168, Australia

[10] Univ Melbourne, Peter MacCallum Canc Ctr, Canc Res Div, Canc Res Program, Melbourne, Vic 3000, Australia

[11] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3000, Australia

[12] Monash Univ, Monash Biomed Discovery Inst, Dept Physiol, Prostate Canc Res Grp,Monash Partners Comprehens, Clayton, Vic 3168, Australia

[13] South Australian Hlth & Med Res Inst, Adelaide, SA 5000, Australia

[14] Univ Adelaide, Fac Hlth & Med Sci, Adelaide, SA 5005, Australia

[15] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada

[16] Univ Adelaide, Sch Biol Sci, Adelaide, SA 5005, Australia

[17] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Bedford Pk, SA 5042, Australia

来源：

CELL REPORTS | 2021年 / 34卷 / 01期

基金：

英国医学研究理事会;

关键词：

TRANSCRIPTION FACTORS; MAMMALIAN MICRORNAS; LINEAGE PLASTICITY; RECEPTOR; DIFFERENTIATION; ACTIVATION; REVEALS; BINDING; FOXA1; IDENTIFICATION;

D O I：

10.1016/j.celrep.2020.108585

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to the emergence of neuroendocrine prostate cancer (NEPC), a phenomenon associated with enhanced cell plasticity. Here, we show that microRNA-194 (miR-194) is a regulator of epithelial-neuroendocrine transdifferentiation. In clinical prostate cancer samples, miR-194 expression and activity were elevated in NEPC and inversely correlated with AR signaling. miR-194 facilitated the emergence of neuroendocrine features in prostate cancer cells, a process mediated by its ability to directly target a suite of genes involved in cell plasticity. One such target was FOXA1, which encodes a transcription factor with a vital role in maintaining the prostate epithelial lineage. Importantly, a miR-194 inhibitor blocked epithelial-neuroendocrine transdifferentiation and inhibited the growth of cell lines and patient-derived organoids possessing neuroendocrine features. Overall, our study reveals a post-transcriptional mechanism regulating the plasticity of prostate cancer cells and provides a rationale for targeting miR-194 in NEPC.

引用

页数：23

共 104 条

[11] The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer [J].

Bishop, Jennifer L. ;

Thaper, Daksh ;

Vahid, Sepideh ;

Davies, Alastair ;

Ketola, Kirsi ;

Kuruma, Hidetoshi ;

Jama, Randy ;

Nip, Ka Mun ;

Angeles, Arkhjamil ;

Johnson, Fraser ;

Wyatt, Alexander W. ;

Fazli, Ladan ;

Gleave, Martin E. ;

Lin, Dong ;

Rubin, Mark A. ;

Collins, Colin C. ;

Wang, Yuzhuo ;

Beltran, Himisha ;

Zoubeidi, Amina .

CANCER DISCOVERY, 2017, 7 (01) :54-71

[12] Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling [J].

Bluemn, Eric G. ;

Coleman, Ilsa M. ;

Lucas, Jared M. ;

Coleman, Roger T. ;

Hernandez-Lopez, Susana ;

Tharakan, Robin ;

Bianchi-Frias, Daniella ;

Dumpit, Ruth F. ;

Kaipainen, Arja ;

Corella, Alexandra N. ;

Yang, Yu Chi ;

Nyquist, Michael D. ;

Mostaghel, Elahe ;

Hsieh, Andrew C. ;

Zhang, Xiaotun ;

Corey, Eva ;

Brown, Lisha G. ;

Nguyen, Holly M. ;

Pienta, Kenneth ;

Ittmann, Michael ;

Schweizer, Michael ;

True, Lawrence D. ;

Wise, David ;

Rennie, Paul S. ;

Vessella, Robert L. ;

Morrissey, Colm ;

Nelson, Peter S. .

CANCER CELL, 2017, 32 (04) :474-+

[13] Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion [J].

Bracken, Cameron P. ;

Li, Xiaochun ;

Wright, Josephine A. ;

Lawrence, David M. ;

Pillman, Katherine A. ;

Salmanidis, Marika ;

Anderson, Matthew A. ;

Dredge, B. Kate ;

Gregory, Philip A. ;

Tsykin, Anna ;

Neilsen, Corine ;

Thomson, Daniel W. ;

Bert, Andrew G. ;

Leerberg, Joanne M. ;

Yap, Alpha S. ;

Jensen, Kirk B. ;

Khew-Goodall, Yeesim ;

Goodall, Gregory J. .

EMBO JOURNAL, 2014, 33 (18) :2040-2056

[14] Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation [J].

Broutier, Laura ;

Andersson-Rolf, Amanda ;

Hindley, Christopher J. ;

Boj, Sylvia F. ;

Clevers, Hans ;

Koo, Bon-Kyoung ;

Huch, Meritxell .

NATURE PROTOCOLS, 2016, 11 (09) :1724-1743

[15] NAR Breakthrough Article Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies [J].

Chan, Siu Chiu ;

Selth, Luke A. ;

Li, Yingming ;

Nyquist, Michael D. ;

Miao, Lu ;

Bradner, James E. ;

Raj, Ganesh V. ;

Tilley, Wayne D. ;

Dehm, Scott M. .

NUCLEIC ACIDS RESEARCH, 2015, 43 (12) :5880-5897

[16] Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps [J].

Chi, Sung Wook ;

Zang, Julie B. ;

Mele, Aldo ;

Darnell, Robert B. .

NATURE, 2009, 460 (7254) :479-486

[17] Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer [J].

Ci, Xinpei ;

Hao, Jun ;

Dong, Xin ;

Choi, Stephen Y. ;

Xue, Hui ;

Wu, Rebecca ;

Qu, Sifeng ;

Gout, Peter W. ;

Zhang, Fang ;

Haegert, Anne M. ;

Fazli, Ladan ;

Crea, Francesco ;

Ong, Christopher J. ;

Zoubeidi, Amina ;

He, Housheng H. ;

Gleave, Martin E. ;

Collins, Colin C. ;

Lin, Dong ;

Wang, Yuzhuo .

CANCER RESEARCH, 2018, 78 (10) :2691-2704

[18] N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer [J].

Dardenne, Etienne ;

Beltran, Himisha ;

Benelli, Matteo ;

Gayvert, Kaitlyn ;

Berger, Adeline ;

Puca, Loredana ;

Cyrta, Joanna ;

Sboner, Andrea ;

Noorzad, Zohal ;

MacDonald, Theresa ;

Cheung, Cynthia ;

Yuen, Ka Shing ;

Gao, Dong ;

Chen, Yu ;

Eilers, Martin ;

Mosquera, Juan-Miguel ;

Robinson, Brian D. ;

Elemento, Olivier ;

Rubin, Mark A. ;

Demichelis, Francesca ;

Rickman, David S. .

CANCER CELL, 2016, 30 (04) :563-577

[19] MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2 [J].

Das, Rajdeep ;

Gregory, Philip A. ;

Fernandes, Rayzel C. ;

Denis, Iza ;

Wang, Qingqing ;

Townley, Scott L. ;

Zhao, Shuang G. ;

Hanson, Adrienne R. ;

Pickering, Marie A. ;

Armstrong, Heather K. ;

Lokman, Noor A. ;

Ebrahimie, Esmaeil ;

Davicioni, Elai ;

Jenkins, Robert B. ;

Karnes, R. Jeffrey ;

Ross, Ashley E. ;

Den, Robert B. ;

Klein, Eric A. ;

Chi, Kim N. ;

Ramshaw, Hayley S. ;

Williams, Elizabeth D. ;

Zoubeidi, Amina ;

Goodall, Gregory J. ;

Feng, Felix Y. ;

Butler, Lisa M. ;

Tilley, Wayne D. ;

Selth, Luke A. .

CANCER RESEARCH, 2017, 77 (04) :1021-1034

[20] The epigenetic and transcriptional landscape of neuroendocrine prostate cancer [J].

Davies, Alastair ;

Zoubeidi, Amina ;

Selth, Luke A. .

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