A traffic jam leads to Lewy bodies

被引：8

作者：

Bartels, Tim ^{[1
,2
,3
]}

机构：

[1] UCL, Dementia Res Inst, London, England

[2] Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, 75 Francis St, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

来源：

NATURE NEUROSCIENCE | 2019年 / 22卷 / 07期

关键词：

ALPHA-SYNUCLEIN TETRAMERS; VESICLES; DISEASE;

D O I：

10.1038/s41593-019-0435-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

引用

页码：1043 / 1045

页数：4

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