Prognostic value of matrix Gla protein in breast cancer

被引：30
|
作者：
Yoshimura, Keiko [6 ]
Takeuchi, Kengo [2 ]
Nagasaki, Koichi
Ogishima, Soichi [4 ]
Tanaka, Hiroshi [4 ]
Iwase, Takuji [3 ]
Akiyama, Futoshi [2 ]
Kuroda, Yoshikazu [6 ]
Miki, Yoshio [1 ,5 ]
机构：
[1] Japanese Fdn Canc Res, Genome Ctr, Koto Ku, Tokyo 1358550, Japan
[2] Canc Inst Hosp, Div Pathol, Tokyo 1358550, Japan
[3] Canc Inst Hosp, Div Breast Oncol, Tokyo 1358550, Japan
[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Bioinformat, Tokyo 1138519, Japan
[5] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Genet, Tokyo 1138519, Japan
[6] Kobe Univ, Grad Sch Med, Dept Surg, Kobe, Hyogo 6500017, Japan
来源：
MOLECULAR MEDICINE REPORTS | 2009年 / 2卷 / 04期
关键词：
breast cancer; matrix Gla protein; gene expression microarray; tissue microarray; MESSENGER-RNA; GENE-EXPRESSION; CELLS; BONE; ACID;
D O I：
10.3892/mmr_00000135
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To assess the prognostic value of matrix Gla protein (MGP) expression in cases of breast cancer, 9 samples from patients diagnosed with breast cancer who were followed up for more than 10 years were microdissected and then analyzed using Affymetrix U133 Plus 2.0 Arrays. Genes that exhibited significant differences in expression between patients with a good prognosis and those with a poor prognosis were identified. The MGP gene was among the genes up-regulated in cases where the prognosis was poor, indicating that the mRNA levels of MGP are a potential prognostic indicator of breast cancer. However, immunohistostaining of breast tissue microarrays (n=207) did not reveal a correlation between the protein expression of MGP and overall survival, neither was there a correlation between the protein expression of MGP and ER status or bone metastasis. In breast cancer cases, the mRNA level of MGP may be a marker indicating poor prognosis; however, protein expression determined by immunohistostaining is not.
引用
收藏
页码：549 / 553
页数：5
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