Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

被引:65
作者
Fujie, Shumpei [1 ]
Hasegawa, Natsuki [1 ]
Sato, Koji [1 ]
Fujita, Satoshi [1 ]
Sanada, Kiyoshi [1 ]
Hamaoka, Takafumi [1 ]
Iemitsu, Motoyuki [1 ]
机构
[1] Ritsumeikan Univ, Fac Sport & Hlth Sci, Kusatsu, Shiga 5258577, Japan
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2015年 / 309卷 / 10期
关键词
aging; adropin; carotid beta-stiffness; exercise training; nitric oxide; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; HYPERTENSIVE PATIENTS; ENDOTHELIAL FUNCTION; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; NITRIC-OXIDE; DEFICIENCY; EXPRESSION; DISEASE;
D O I
10.1152/ajpheart.00338.2015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middleaged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 +/- 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 +/- 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid beta-stiffness (r = -0.437, P < 0.001) and positively correlated with plasma NOx level (r = 0.493, P < 0.001) and cardiorespiratory fitness (r = 0.457, P < 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training- induced changes in serum adropin level were correlated with traininginduced changes in carotid beta-stiffness (r = -0.399, P < 0.05) and plasma NOx level (r = 0.623, P < 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness.
引用
收藏
页码:H1642 / H1647
页数:6
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