Localized chromophobe carcinomas treated by nephron-spanng surgery have excellent oncologic outcomes

被引：3

作者：

Bigot, Pierre ^{[1
,2
,3
,25
]}

Bernhard, Jean-Christophe ^{[1
,2
,4
,25
]}

Flamand, Vincent ^{[2
,5
,25
]}

Gill, Inderbir ^{[6
,25
]}

Verhoest, Gregory ^{[2
,7
,25
]}

Beauval, Jean Baptiste ^{[2
,8
,25
]}

Nouhaud, Francois Xavier ^{[2
,9
,25
]}

Suer, Evren ^{[10
,25
]}

Ploussard, Guillaume ^{[1
,11
,25
]}

Francois, Jean ^{[1
,12
,25
]}

Rigaud, Jerome ^{[1
,13
,25
]}

Baco, Eduard ^{[14
,25
]}

Larre, Stephane ^{[1
,15
,25
]}

Sebe, Philippe ^{[1
,16
,25
]}

Koutlidis, Nicolas ^{[17
,25
]}

Descazeaud, Aurelien ^{[2
,18
,25
]}

Eto, Masatoshi ^{[19
,25
]}

Doerfler, Arnaud ^{[20
,25
]}

Roupret, Morgan ^{[1
,21
,22
,25
]}

Vuong, Nam Son ^{[4
,25
]}

Reix, Boris ^{[5
,25
]}

Matsugasumi, Tom ^{[6
,25
]}

El Bakri, Adnan ^{[15
,25
]}

Albiges, Laurence ^{[1
,23
,25
]}

Soulie, Michel ^{[1
,2
,8
,25
]}

Patard, Jean-Jacques ^{[1
,2
,23
,25
]}

Mejean, Arnaud ^{[1
,2
,24
,25
]}

Bensalah, Karim ^{[1
,2
,25
]}

机构：

[1] French Assoc Urol CCAFU, Cancerol Comm, Paris, France

[2] French Network Res Kidney Canc UroCCR, Bordeaux, France

[3] Angers Univ Hosp, Dept Urol, Angers, France

[4] Bordeaux Univ Hosp, Dept Urol, Bordeaux, France

[5] Lille Univ Hosp, Dept Urol, Lille, France

[6] Univ Southern Calif, Inst Urol, Los Angeles, CA USA

[7] Pontchaillou Univ Hosp, Dept Urol, Rennes, France

[8] Toulouse Univ Hosp, Dept Urol, Toulouse, France

[9] Rouen Univ Hosp, Dept Urol, Rouen, France

[10] Univ Hosp Ankara, Dept Urol, Ankara, Turkey

[11] St Louis Univ Hosp, AP HP, Dept Urol, Paris, France

[12] Clin Jules Vernes, Dept Urol, Nantes, France

[13] Nantes Univ Hosp, Dept Urol, Nantes, France

[14] Univ Hosp Oslo, Dept Urol, Oslo, Norway

[15] Reims Univ Hosp, Dept Urol, Reims, France

[16] Grp Hosp Diaconesses, Dept Urol, Paris, France

[17] Dijon Univ Hosp, Dept Urol, Dijon, France

[18] Limoges Univ Hosp, Dept Urol, Limoges, France

[19] Kumamoto Univ Hosp, Dept Urol, Kumamoto, Japan

[20] Caen Univ Hosp, Dept Urol, Caen, France

[21] AP HP, La Pitie Salpetriere, Dept Urol, Paris, France

[22] Univ Paris 06, Fac Med Pierre & Marie Curie, Paris, France

[23] Univ Paris 11, Dept Med Oncol, Villejuif, France

[24] AP HP, HEGP, Dept Urol, Paris, France

[25] Bicetre Univ Hosp, Dept Urol, Le Kremlin Bicetre, France

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2017年 / 35卷 / 01期

关键词：

Nephron-sparing surgery; Chromophobe renal carcinoma; Oncologic outcomes; RENAL-CELL CARCINOMA; HOGG-DUBE-SYNDROME; PARTIAL NEPHRECTOMY; RADICAL NEPHRECTOMY; TUMORS; EXPERIENCE; SURVIVAL; DISEASE; IMPACT;

D O I：

10.1016/j.urolonc.2016.08.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To evaluate the oncologic outcomes of nephron-sparing surgery (NSS) for localized chromophobe renal cell carcinoma (cRCC). Material and methods: We performed a multicenter international study involving the French Network for Research on Kidney Cancer (UroCCR) and 5 international teams. Data from 808 patients treated with NSS between 2004 and 2014 for non clear cell RCCs were analyzed. Results: We included 234 patients with cRCC. There were 123 (52.6%) females. Median age was 61 (23-88) years. Median tumor size was 3 (1-11) cm. A positive surgical margin was identified in 14 specimens (6%). Pathologic stages were T1, T2, and T3a in 202 (86.3%), 9 (3.8%), and 23 (9.8%) cases, respectively. After a mean follow-up of 46.6 36 months, 2 (0.8%) patients experienced a local recurrence. No patient had metastatic progression, and no patient died from cancer. Three -years estimated cancer -free survival and cancer -specific survival were 99.1% and 100%, respectively. Conclusion: Oncological results of NSS for localized cRCC are excellent. In this series, only 2 patients had a local recurrence, and no patient had metastatic progression or died from cancer. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：35.e15 / 35.e19

页数：5

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