Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances

被引：103
作者：
Cheng, Bo [1 ,2 ]
Xie, Ran [1 ,2 ]
Dong, Lu [1 ,2 ]
Chen, Xing [1 ,2 ]
机构：
[1] Peking Univ, Synthet & Funct Biomolecules Ctr, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[2] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
来源：
CHEMBIOCHEM | 2016年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
bioorthogonal chemistry; chemical reporters; click chemistry; metabolic glycan labeling; sialic acids; ACYL SIDE-CHAIN; BIOORTHOGONAL CHEMICAL REPORTERS; N-ACETYLMANNOSAMINE ANALOGS; FREE CLICK CHEMISTRY; POLYSIALIC ACID; IN-VIVO; CROSS-LINKING; LIVING ANIMALS; D-MANNOSAMINE; CANCER-CELLS;
D O I：
10.1002/cbic.201500344
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-surface sialic acids are essential in mediating a variety of physiological and pathological processes. Sialic acid chemistry and biology remain challenging to investigate, demanding new tools for probing sialylation in living systems. The metabolic glycan labeling (MGL) strategy has emerged as an invaluable chemical biology tool that enables metabolic installation of useful functionalities into cell-surface sialoglycans by hijacking the sialic acid biosynthetic pathway. Here we review the principles of MGL and its applications in study and manipulation of sialic acid function, with an emphasis on recent advances.
引用
收藏
页码：11 / 27
页数：17
相关论文
共 168 条
  • [1] A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of blomolecules in living systems
    Agard, NJ
    Prescher, JA
    Bertozzi, CR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (46) : 15046 - 15047
  • [2] A Pictet-Spengler ligation for protein chemical modification
    Agarwal, Paresh
    van der Weijden, Joep
    Sletten, Ellen M.
    Rabuka, David
    Bertozzi, Carolyn R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (01) : 46 - 51
  • [3] Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo
    Andersen, Kristen A.
    Aronoff, Matthew R.
    McGrath, Nicholas A.
    Raines, Ronald T.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (07) : 2412 - 2415
  • [4] Chemical diversity in the sialic acids and related α-keto acids:: An evolutionary perspective
    Angata, T
    Varki, A
    [J]. CHEMICAL REVIEWS, 2002, 102 (02) : 439 - 469
  • [5] Identification of Novel Tumor-Associated Cell Surface Sialoglycoproteins in Human Glioblastoma Tumors Using Quantitative Proteomics
    Autelitano, Francois
    Loyaux, Denis
    Roudieres, Sebastien
    Deon, Catherine
    Guette, Frederique
    Fabre, Philippe
    Ping, Qinggong
    Wang, Su
    Auvergne, Romane
    Badarinarayana, Vasudeo
    Smith, Michael
    Guillemot, Jean-Claude
    Goldman, Steven A.
    Natesan, Sridaran
    Ferrara, Pascual
    August, Paul
    [J]. PLOS ONE, 2014, 9 (10):
  • [6] Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells
    Bardor, M
    Nguyen, DH
    Diaz, S
    Varki, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) : 4228 - 4237
  • [7] Copper-free click chemistry for dynamic in vivo imaging
    Baskin, Jeremy M.
    Prescher, Jennifer A.
    Laughlin, Scott T.
    Agard, Nicholas J.
    Chang, Pamela V.
    Miller, Isaac A.
    Lo, Anderson
    Codelli, Julian A.
    Bertozzi, Carolyn R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) : 16793 - 16797
  • [8] N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation
    Bateman, Leslie A.
    Zaro, Balyn W.
    Chuh, Kelly N.
    Pratt, Matthew R.
    [J]. CHEMICAL COMMUNICATIONS, 2013, 49 (39) : 4328 - 4330
  • [9] GUEST EDITORIAL A Decade of Bioorthogonal Chemistry
    Bertozzi, Carolyn R.
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (09) : 651 - 653
  • [10] Besanceney-Webler C., 2011, ANGEW CHEM, V123, P8201, DOI DOI 10.1002/ANGE.201101817
12345678910