Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds

被引：210

作者：

Scott, Daniel J. ^{[1
]}

Fuchter, Matthew J. ^{[1
]}

Ashley, Andrew E. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 45期

基金：

英国工程与自然科学研究理事会;

关键词：

HOMOGENEOUS HYDROGENATION; METAL; HYDROSILATION; ACTIVATION; MECHANISM; ACIDITY; ETHERS;

D O I：

10.1021/ja5088979

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solutions of the Lewis acid B(C6F5)(3) in 1,4-dioxane are found to effectively catalyze the hydrogenation of a variety of ketones and aldehydes. These reactions, the first to allow entirely metal-free catalytic hydrogenation of carbonyl groups under relatively mild reaction conditions, are found to proceed via a frustrated Lewis pair mechanism in which the solvent, a weak Bronsted base yet moderately strong donor, plays a pivotal role.

引用

页码：15813 / 15816

页数：4

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