Analysis of Association Between Polymorphism of TFB2M Gene and Meat Quality, Growth and Slaughter Traits in Guizhou White Goat, a Well-known Chinese Indigenous Goat Breed

被引:0
作者
Sun, Yanyan [1 ]
Luo, Weixing [1 ]
Xie, Haiqiang [1 ]
Zhang, Yiyu [1 ]
Cai, Huifen [1 ]
机构
[1] Guizhou Univ, Coll Zool,Minist Educ, Key Lab Anim Genet Breeding & Reprod Guizhou Prov, Key Lab Anim Genet Breeding & Reprod Plateau Mt R, Guiyang 550025, Guizhou, Peoples R China
关键词
Guizhou white goat; TFB2M; gene polymorphism; meat quality traits; growth traits; slaughter traits; MITOCHONDRIAL TRANSCRIPTION; RIBOSOMAL-RNA; B1;
D O I
暂无
中图分类号
Q95 [动物学];
学科分类号
071002 ;
摘要
The present study aims to determine the useful SNPs in TFB2M gene and explore their effects on the meat quality in Guizhou White Goat. In this study, the technologies of DNA pool, direct sequencing and PCRSSCP were -adopted to screen the SNPs of TFB2M gene in 29 experimental Guizhou White Goats. We analyzed the association between the polymorphism of TFB2M gene and the growth traits, meat quality traits and slaughter traits in experimental goats. It is shown from the results that A17110C locus was detected in exon 8, and three genotypes (AA, AC and CC) were discovered by SSCP. The association analysis showed that there was no significant difference in growth traits (P>0.05), meanwhile SNPs (A17110C) made a certain influence on bone weight in Guizhou White Goat, and the individuals of genotype AA were superior than genotype AC in bone weight (P<0.05). According to the results in this study, it is suggested that TFB2M gene might be regarded as a candidate gene affecting bone weight in goats.
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页码:1605 / 1610
页数:6
相关论文
共 12 条
[1]  
[陈志 Chen Zhi], 2013, [中国农业科学, Scientia Agricultura Sinica], V46, P1915
[2]   Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression [J].
Cotney, Justin ;
Wang, Zhibo ;
Shadel, Gerald S. .
NUCLEIC ACIDS RESEARCH, 2007, 35 (12) :4042-4054
[3]   Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2 [J].
Cotney, Justin ;
Shadel, Gerald S. .
JOURNAL OF MOLECULAR EVOLUTION, 2006, 63 (05) :707-717
[4]   Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA [J].
Falkenberg, M ;
Gaspari, M ;
Rantanen, A ;
Trifunovic, A ;
Larsson, NG ;
Gustafsson, CM .
NATURE GENETICS, 2002, 31 (03) :289-294
[5]   PURIFICATION AND CHARACTERIZATION OF HUMAN MITOCHONDRIAL TRANSCRIPTION FACTOR-I [J].
FISHER, RP ;
CLAYTON, DA .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3496-3509
[6]  
Huang QinHua Huang QinHua, 2010, Guizhou Agricultural Sciences, P162
[7]   Mitochondrial DNA transcription regulation and nucleoid organization [J].
Rebelo, Adriana P. ;
Dillon, Lloye M. ;
Moraes, Carlos T. .
JOURNAL OF INHERITED METABOLIC DISEASE, 2011, 34 (04) :941-951
[8]   Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop [J].
Seidel-Rogol, BL ;
McCulloch, V ;
Shadel, GS .
NATURE GENETICS, 2003, 33 (01) :23-24
[9]   TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase [J].
Sologub, Marina ;
Litonin, Dmitry ;
Anikin, Michael ;
Mustaev, Arkady ;
Temiakov, Dmitry .
CELL, 2009, 139 (05) :934-944
[10]  
[宋桃伟 Song Taowei], 2013, [畜牧兽医学报, Acta Veterinaria et Zootechnica Sinica], V44, P1717