Liver enzymeCYP2D6gene and tardive dyskinesia

被引：5

作者：

Lu, Justin Y. ^{[1
]}

Tiwari, Arun K. ^{[1
,2
]}

Freeman, Natalie ^{[1
]}

Zai, Gwyneth C. ^{[1
,2
,3
]}

Luca, Vincenzo de ^{[1
,2
,3
]}

Mueller, Daniel J. ^{[1
,2
,3
]}

Tampakeras, Maria ^{[1
]}

Herbert, Deanna ^{[1
]}

Emmerson, Heather ^{[1
]}

Cheema, Sheraz Y. ^{[1
]}

King, Nicole ^{[1
]}

Voineskos, Aristotle N. ^{[2
,3
]}

Potkin, Steven G. ^{[4
]}

Lieberman, Jeffrey A. ^{[5
]}

Meltzer, Herbert Y. ^{[6
]}

Remington, Gary ^{[1
,2
,3
]}

Kennedy, James L. ^{[1
,2
,3
]}

Zai, Clement C. ^{[1
,2
,3
,7
]}

机构：

[1] Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Tanenbaum Ctr Pharmacogenet, Toronto, ON M5T 1R8, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada

[3] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada

[4] Univ Calif Irvine, Long Beach Vet Adm Hlth Care Syst, Dept Psychiat & Human Behav, Irvine, CA 92617 USA

[5] Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USA

[6] Northwestern Univ, Feinberg Sch Med, Chem Life Proc Inst, Psychiat & Behav Sci,Pharmacol & Physiol, Chicago, IL 60611 USA

[7] Univ Toronto, Lab Med Pathobiol, Toronto, ON M5S 1A8, Canada

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 15期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

metabolizer phenotype; pharmacogenetics; schizophrenia; tardive dyskinesia; CYTOCHROME-P450; 2D6; FAMILIAL OCCURRENCE; CYP2D6; GENOTYPE; RECEPTOR GENE; SCHIZOPHRENIA; ASSOCIATION; POLYMORPHISM; RISK; RISPERIDONE;

D O I：

10.2217/pgs-2020-0065

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background:Tardive dyskinesia (TD) is an iatrogenic involuntary movement disorder occurring after extended antipsychotic use with an unclear pathogenesis.CYP2D6is a liver enzyme involved in antipsychotic metabolism and a well-studied gene candidate for TD.Materials & methods:We tested predicted CYP2D6 metabolizer phenotype with TD occurrence and severity in our two samples of European chronic schizophrenia patients (total n = 198, of which 82 had TD).Results:TD occurrence were associated with extreme metabolizer phenotype, controlling for age and sex (p = 0.012). In other words, individuals with either increased and no CYP2D6 activity were at higher risk of having TD.Conclusion:Unlike most previous findings, TD occurrence may be associated with both extremes of CYP2D6 metabolic activity rather than solely for poor metabolizers.

引用

页码：1065 / 1072

页数：8

共 43 条

[1] Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia [J].