Ni(II)-Catalyzed Oxidative Coupling between C(sp2)-H in Benzamides and C(sp3)-H in Toluene Derivatives

被引：222

作者：

Aihara, Yoshinori ^{[1
]}

Tobisu, Mamoru ^{[1
]}

Fukumoto, Yoshiya ^{[1
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 44期

关键词：

CATALYZED ORTHO-ARYLATION; H BOND ACTIVATION; C-C; PERFLUOROALKYL IODIDES; ALKYL-HALIDES; SIMPLE ARENES; FLUOROALKYLATION; FUNCTIONALIZATION;

D O I：

10.1021/ja5095342

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidative coupling between C((sp2)))-H bonds and C((sp3)))-H bonds is achieved by the Ni(II)-catalyzed reaction of benzamides containing an 8-aminoquinoline moiety as the directing group with toluene derivatives in the presence of heptafluoroisopropyl iodide as the oxidant. The method has a broad scope and shows high functional group compatibility. Toluene derivatives can be used as the coupling partner in an unreactive solvent.

引用

页码：15509 / 15512

页数：4

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