Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

被引：982
作者：
Peckham, Hannah [1 ,2 ]
de Gruijter, Nina M. [1 ,2 ]
Raine, Charles [2 ]
Radziszewska, Anna [1 ,2 ]
Ciurtin, Coziana [1 ,2 ]
Wedderburn, Lucy R. [1 ,3 ,4 ]
Rosser, Elizabeth C. [1 ,2 ]
Webb, Kate [5 ,6 ]
Deakin, Claire T. [1 ,3 ,4 ]
机构：
[1] UCL, UCLH, Ctr Adolescent Rheumatol Versus Arthrit, GOSH, London, England
[2] UCL, Ctr Rheumatol Res, Div Med, London, England
[3] UCL Great Ormond St Inst Child Hlth, Infect Immun & Inflammat Res & Teaching Dept, London, England
[4] Great Ormond St Hosp Sick Children, NIHR Biomed Res Ctr, London, England
[5] Univ Cape Town, Red Cross War Mem Childrens Hosp, Sch Child & Adolescent Hlth, Dept Paediat Rheumatol, Cape Town, South Africa
[6] Crick African Network, Francis Crick Inst, London, England
来源：
NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期
基金：
英国医学研究理事会;
关键词：
PLASMACYTOID DENDRITIC CELLS; IFN-ALPHA PRODUCTION; GENDER-DIFFERENCES; X-CHROMOSOME; RESPIRATORY SYNDROME; MEDIATED RESPONSE; ESTROGEN; AGE; TESTOSTERONE; EXPRESSION;
D O I：
10.1038/s41467-020-19741-6
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR=2.84; 95% CI=2.06, 3.92) and higher odds of death (OR=1.39; 95% CI=1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease.
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页数：10
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