Drug Delivery across Barriers to the Middle and Inner Ear

被引：55

作者：

Zhang, Zipei ^{[1
]}

Li, Xiyu ^{[1
]}

Zhang, Wei ^{[1
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Anesthesiol, Div Crit Care Med, Lab Biomat & Drug Delivery,Boston Childrens Hosp, Boston, MA 02115 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2021年 / 31卷 / 44期

关键词：

drug delivery; invasive; noninvasive; trans‐ tympanic; ROUND WINDOW MEMBRANE; ACUTE OTITIS-MEDIA; SUSTAINED-RELEASE; TYMPANIC MEMBRANE; THICKNESS DISTRIBUTION; PENETRATION ENHANCERS; NANOPARTICLES; DEXAMETHASONE; HYDROGEL; CHITOSAN;

D O I：

10.1002/adfm.202008701

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed. Such methods are either non-invasive (placed on the surface of the TM), or invasive (placed in the middle ear, ideally on the round window [RW]). The major hurdles to otic drug delivery are identified and highlighted the representative examples of drug delivery systems used for drug delivery across the TM to the middle and (crossing the RW also) inner ear.

引用

页数：12

共 138 条

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