Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina

被引：11
|
作者：
Lara, Julia [1 ]
Cohen, Melina [1 ]
De Matteo, Elena [2 ]
Aversa, Luis [3 ]
Victoria Preciado, Maria [1 ]
Chabay, Paola [1 ]
机构：
[1] Ricardo Gutierrez Childrens Hosp, Mol Biol Lab, Div Pathol, Buenos Aires, DF, Argentina
[2] Ricardo Gutierrez Childrens Hosp, Div Pathol, Buenos Aires, DF, Argentina
[3] Ricardo Gutierrez Childrens Hosp, Div Hematol, Buenos Aires, DF, Argentina
来源：
JOURNAL OF MEDICAL VIROLOGY | 2014年 / 86卷 / 05期
关键词：
lymphoma; LMP1; latency; EBV; BHRF1; childhood; EXPRESSION; BRAZIL;
D O I：
10.1002/jmv.23737
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression. J. Med. Virol. 86:845-850, 2014. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：845 / 850
页数：6
相关论文
共 50 条
  • [41] Changing trend of Epstein-Barr virus association in Hodgkin lymphoma in the Republic of Korea
    Koh, Young Wha
    Kang, Hyo Jeong
    Yoon, Dok Hyun
    Suh, Cheolwon
    Kim, Ji Eun
    Kim, Chul-Woo
    Huh, Jooryung
    ANNALS OF HEMATOLOGY, 2013, 92 (12) : 1653 - 1660
  • [42] Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells
    Renouf, B.
    Hollville, E.
    Pujals, A.
    Tetaud, C.
    Garibal, J.
    Wiels, J.
    LEUKEMIA, 2009, 23 (09) : 1557 - 1563
  • [43] ASSOCIATION OF EPSTEIN-BARR VIRUS (EBV) BUT NOT HUMAN PAPILLOMAVIRUS (HPV) WITH GINGIVITIS AND/OR PERIODONTITIS IN TRANSPLANTED INDIVIDUALS
    Baez, Camila Freze
    Savassi-Ribas, Flavia
    da Rocha, Wilker Menezes
    Almeida, Stephanie G. S.
    Goncalves, Marianna T. V.
    Guimaraes, Maria Angelica A. M.
    Cavalcanti, Silvia Maria B.
    Varella, Rafael B.
    REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 2016, 58
  • [44] Comparative Proteomic Analysis Implicates COMMD Proteins as Epstein-Barr Virus Targets in the BL41 Burkitt's Lymphoma Cell Line
    Gkiafi, Zacharati
    Panayotou, George
    JOURNAL OF PROTEOME RESEARCH, 2011, 10 (07) : 2959 - 2968
  • [45] Analysis of SH2D1A mutations in patients with severe Epstein-Barr virus infections, Burkitt's lymphoma, and Hodgkin's lymphoma
    Parolini, O
    Kagerbauer, B
    Simonitsch-Klupp, I
    Ambros, P
    Jaeger, U
    Mann, G
    Haas, OA
    Morra, M
    Gadner, H
    Terhorst, C
    Knapp, W
    Holter, W
    ANNALS OF HEMATOLOGY, 2002, 81 (08) : 441 - 447
  • [46] How accurate are diagnostic tools for Epstein-Barr virus (EBV) to establish causal association of an uncommon clinical condition with EBV?
    Neocleous, C.
    Adramerina, A.
    Spanou, C.
    Spyrou, G.
    Mitsios, A.
    Dragoumi, M.
    Tzanetis, F.
    ACTA VIROLOGICA, 2013, 57 (03) : 283 - 291
  • [47] Analysis of gene expression differences pre- and post-lytic reactivation of Epstein-Barr virus in Burkitt's lymphoma
    Gong, Zhiyuan
    Liu, Wen
    Luo, Bing
    FUTURE VIROLOGY, 2024, 19 (6-7) : 229 - 237
  • [48] Resveratrol Inhibits Proliferation and Survival of Epstein Barr Virus-Infected Burkitt's Lymphoma Cells Depending on Viral Latency Program
    De Leo, Alessandra
    Arena, Giuseppe
    Stecca, Claudia
    Raciti, Marisa
    Mattia, Elena
    MOLECULAR CANCER RESEARCH, 2011, 9 (10) : 1346 - 1355
  • [49] Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines
    Perez-Chacon, Gema
    de los Rios, Cristobal
    Zapata, Juan M.
    PHARMACOLOGICAL RESEARCH, 2014, 89 : 46 - 56
  • [50] PARALLEL EXISTENCE OF EPSTEIN-BARR-VIRUS (EBV) POSITIVE AND NEGATIVE CELLS IN A SPORADIC CASE OF BURKITT-LYMPHOMA
    TRIVEDI, P
    ZHANG, QJ
    CHEN, F
    MINAROVITS, J
    EKMAN, M
    BIBERFELD, P
    KLEIN, G
    WINBERG, G
    ONCOGENE, 1995, 11 (03) : 505 - 510
12345