Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina

被引：11
|
作者：
Lara, Julia [1 ]
Cohen, Melina [1 ]
De Matteo, Elena [2 ]
Aversa, Luis [3 ]
Victoria Preciado, Maria [1 ]
Chabay, Paola [1 ]
机构：
[1] Ricardo Gutierrez Childrens Hosp, Mol Biol Lab, Div Pathol, Buenos Aires, DF, Argentina
[2] Ricardo Gutierrez Childrens Hosp, Div Pathol, Buenos Aires, DF, Argentina
[3] Ricardo Gutierrez Childrens Hosp, Div Hematol, Buenos Aires, DF, Argentina
来源：
JOURNAL OF MEDICAL VIROLOGY | 2014年 / 86卷 / 05期
关键词：
lymphoma; LMP1; latency; EBV; BHRF1; childhood; EXPRESSION; BRAZIL;
D O I：
10.1002/jmv.23737
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression. J. Med. Virol. 86:845-850, 2014. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：845 / 850
页数：6
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