Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina

被引：11

作者：

Lara, Julia ^{[1
]}

Cohen, Melina ^{[1
]}

De Matteo, Elena ^{[2
]}

Aversa, Luis ^{[3
]}

Victoria Preciado, Maria ^{[1
]}

Chabay, Paola ^{[1
]}

机构：

[1] Ricardo Gutierrez Childrens Hosp, Mol Biol Lab, Div Pathol, Buenos Aires, DF, Argentina

[2] Ricardo Gutierrez Childrens Hosp, Div Pathol, Buenos Aires, DF, Argentina

[3] Ricardo Gutierrez Childrens Hosp, Div Hematol, Buenos Aires, DF, Argentina

来源：

JOURNAL OF MEDICAL VIROLOGY | 2014年 / 86卷 / 05期

关键词：

lymphoma; LMP1; latency; EBV; BHRF1; childhood; EXPRESSION; BRAZIL;

D O I：

10.1002/jmv.23737

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression. J. Med. Virol. 86:845-850, 2014. (c) 2013 Wiley Periodicals, Inc.

引用

页码：845 / 850

页数：6