Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: Experience of a single institution in Argentina

被引:11
作者
Lara, Julia [1 ]
Cohen, Melina [1 ]
De Matteo, Elena [2 ]
Aversa, Luis [3 ]
Victoria Preciado, Maria [1 ]
Chabay, Paola [1 ]
机构
[1] Ricardo Gutierrez Childrens Hosp, Mol Biol Lab, Div Pathol, Buenos Aires, DF, Argentina
[2] Ricardo Gutierrez Childrens Hosp, Div Pathol, Buenos Aires, DF, Argentina
[3] Ricardo Gutierrez Childrens Hosp, Div Hematol, Buenos Aires, DF, Argentina
关键词
lymphoma; LMP1; latency; EBV; BHRF1; childhood; EXPRESSION; BRAZIL;
D O I
10.1002/jmv.23737
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression. J. Med. Virol. 86:845-850, 2014. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:845 / 850
页数:6
相关论文
共 21 条
[1]   Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays [J].
Bell, Andrew I. ;
Groves, Katherine ;
Kelly, Gemma L. ;
Croom-Carter, Debbie ;
Hui, Edwin ;
Chan, Anthony T. C. ;
Rickinson, Alan B. .
JOURNAL OF GENERAL VIROLOGY, 2006, 87 :2885-2890
[2]  
Brady G, 2007, J CLIN PATHOL, V60, P1397, DOI 10.1136/jcp.2007.047977
[3]   EBV-associated lymphoproliferative disorders: Classification and treatment [J].
Carbone, Antonino ;
Gloghini, Annunziata ;
Dotti, Giampietro .
ONCOLOGIST, 2008, 13 (05) :577-585
[4]  
Chabay P, 1999, REV HOSP NINOS B AIR, V41, P88
[5]   Pediatric Hodgkin lymphoma in 2 South American series: A distinctive epidemiologic pattern and lack of association of Epstein-Barr virus with clinical outcome [J].
Chabay, Paola A. ;
Barros, Mario H. M. ;
Hassan, Rocio ;
De Matteo, Elena ;
Rey, Guadalupe ;
Kadma Carrico, Maria ;
Zalcberg Renault, Flana ;
Victoria Preciado, Maria .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2008, 30 (04) :285-291
[6]   Performance characteristics of a reverse transcriptase-polymerase chain reaction assay for the detection of tumor-specific fusion transcripts from archival tissue [J].
Fritsch, MK ;
Bridge, JA ;
Schuster, AE ;
Perlman, EJ ;
Argani, P .
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2003, 6 (01) :43-53
[7]  
God J.M., 2010, Journal of Oncology, V2010, P1
[8]  
GUTIERREZ MI, 1992, BLOOD, V79, P3261
[9]   Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt's lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region [J].
Hassan, Rocio ;
Klumb, Claudete Esteves ;
Felisbino, Fabricio E. ;
Guiretti, Deisy M. ;
White, Lidia R. ;
Stefanoff, Claudio Gustavo ;
Barros, Mario Henrique M. ;
Seuanez, Hector N. ;
Zalcberg, Ilana R. .
HAEMATOLOGICA, 2008, 93 (05) :780-783
[10]   Cellular responses to viral infection in humans: Lessons from Epstein-Barr virus [J].
Hislop, Andrew D. ;
Taylor, Graham S. ;
Sauce, Delphine ;
Rickinson, Alan B. .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :587-617