CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

被引：783
作者：
Li, Shi-Yuan [1 ,2 ]
Cheng, Qiu-Xiang [3 ]
Liu, Jia-Kun [1 ,2 ]
Nie, Xiao-Qun [1 ,2 ]
Zhao, Guo-Ping [1 ,4 ,5 ]
Wang, Jin [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Synthet Biol, Shanghai 200032, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Shanghai Tolo Biotechnol Co Ltd, Shanghai 200233, Peoples R China
[4] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Microbiol, Shatin, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Prince Wales Hosp, Li KaShing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
来源：
CELL RESEARCH | 2018年 / 28卷 / 04期
基金：
中国国家自然科学基金;
关键词：
RNASE ACTIVITIES; CRISPR RNA; CPF1; ENDONUCLEASE; COMPLEX;
D O I：
10.1038/s41422-018-0022-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：491 / 493
页数：3
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