A versatile synthesis of amidines from nitriles via amidoximes

被引：113
作者：
Judkins, BD
Allen, DG
Cook, TA
Evans, B
Sardharwala, TE
机构：
[1] Receptor Chemistry Unit, Glaxo Wellcome R. and D., Medicines Research Centre, Stevenage, Herts, SG1 2NY, Gunnels Wood Road
来源：
SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 23期
关键词：
D O I：
10.1080/00397919608003838
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzamidines were prepared conveniently from benzonitriles in good yield via catalytic hydrogenation of intermediate benzamidoximes in acetic acid/acetic anhydride.
引用
收藏
页码：4351 / 4367
页数：17
相关论文
共 20 条
  • [1] ALIG L, 1992, J MED CHEM, V35, P4407
  • [2] BARBER HJ, Patent No. 551445
  • [3] FORMAMID-REAKTIONEN .9. UMSETZUNGEN DES THIOFORMAMIDS MIT HALOGENVERBINDUNGEN
    BREDERECK, H
    GOMPPER, R
    SEIZ, H
    [J]. CHEMISCHE BERICHTE-RECUEIL, 1957, 90 (09): : 1837 - 1843
  • [4] CARRINGTON HC, 1955, J CHEM SOC, P2527
  • [5] ORALLY-ACTIVE NONPEPTIDE FIBRINOGEN RECEPTOR (GPIIB/IIIA) ANTAGONISTS - IDENTIFICATION OF 4-[4-[4-(AMINOIMINOMETHYL)PHENYL]-1-PIPERAZINYL]-1-PIPERIDINEACETIC ACID AS A LONG-ACTING, BROAD-SPECTRUM ANTITHROMBOTIC AGENT
    ELDRED, CD
    EVANS, B
    HINDLEY, S
    JUDKINS, BD
    KELLY, HA
    KITCHIN, J
    LUMLEY, P
    PORTER, B
    ROSS, BC
    SMITH, KJ
    TAYLOR, NR
    WHEATCROFT, JR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) : 3882 - 3885
  • [6] ELDRED CD, Patent No. 542363
  • [7] ELDRED CD, Patent No. 9322303
  • [8] ELDRED CD, Patent No. 9314077
  • [9] CHEMISTRY OF AMIDOXIMES AND RELATED COMPOUNDS
    ELOY, F
    LENAERS, R
    [J]. CHEMICAL REVIEWS, 1962, 62 (02) : 155 - &
  • [10] GAUTIER JA, 1975, CHEM AMIDINES IMIDAT, V1, P295
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