Linear alkylbenzene sulfonates and intermediate products from their degradation are not estrogenic

被引：11

作者：

Navas, JM

González-Mazo, E

Wenzel, A

Gómez-Parra, A

Segner, H

机构：

[1] UFZ Helmholtz Ctr Environm Res, D-04318 Leipzig, Germany

[2] Univ Cadiz, Fac Ciencias Mar, Dept Quim Fis, Cadiz 11510, Spain

[3] Fraunhofer Inst Umweltchem & Okotoxikol, D-57392 Schmallenberg, Germany

来源：

MARINE POLLUTION BULLETIN | 1999年 / 38卷 / 10期

关键词：

linear alkylbenzene sulfonates; sulfophenyl carboxylates; xenoestrogens; rainbow trout hepatocytes; estrogen receptor;

D O I：

10.1016/S0025-326X(99)00036-3

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A number of natural and man-made chemicals possess estrogenic activity, i.e., they induce receptor-mediated estrogen dependent responses in vertebrates, Recently, high concentrations of linear alkylbenzene sulfonates (LAS) and intermediate products of LAS biodegradation, sulfophenyl carboxylates (SPC), have been found in the Bay of Cadiz, Spain. Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates (APnEO) it has been speculated that LAS and their metabolites have estrogenic effects.. The present work addresses the question upon the passible estrogenicity of LAS and LAS metabolites by two ia vitro assays: the yeast estrogen receptor assay and the vitellogenin assay with cultured trout hepatocytes, With both bioassays no estrogenic effects were observed for any of the compounds tested, (C) 1999 Elsevier Science Ltd, All rights reserved.

引用

页码：880 / 884

页数：5

共 31 条

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