Protein Phase Separation: A New Phase in Cell Biology

被引：1494

作者：

Boeynaems, Steven ^{[1
,2
,3
,4
]}

Alberti, Simon ^{[5
]}

Fawzi, Nicolas L. ^{[6
,7
]}

Mittag, Tanja

Polymenidou, Magdalini ^{[8
]}

Rousseau, Frederic ^{[9
,10
]}

Schymkowitz, Joost ^{[9
,10
]}

Shorter, James ^{[11
]}

Wolozin, Benjamin ^{[12
,13
]}

Van den Bosch, Ludo ^{[2
,3
,4
]}

Tompa, Peter ^{[14
,15
]}

Fuxreiter, Monika ^{[16
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Katholieke Univ Leuven, Dept Neurosci Expt Neurol, Leuven, Belgium

[3] Katholieke Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Leuven, Belgium

[4] VIB, Ctr Brain & Dis Res, Neurobiol Lab, Leuven, Belgium

[5] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany

[6] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA

[7] St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

[8] Univ Zurich, Inst Mol Life Sci, Zurich, Switzerland

[9] VIB, SWITCH Lab, Leuven, Belgium

[10] Katholieke Univ Leuven, Dept Cellular & Mol Med, Leuven, Belgium

[11] Univ Penn, Perelman Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[12] Boston Univ, Sch Med, Dept Pharmacol, Boston, MA 02118 USA

[13] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[14] VUB, VIB, CSB, Brussels, Belgium

[15] Hungarian Acad Sci, Inst Enzymol, Res Ctr Nat Sci, Budapest, Hungary

[16] Univ Debrecen, Dept Biochem & Mol Biol, MTA DE Lab Prot Dynam, Debrecen, Hungary

来源：

TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 06期

基金：

欧洲研究理事会;

关键词：

FRONTOTEMPORAL LOBAR DEGENERATION; INTRINSICALLY DISORDERED PROTEINS; RNA-BINDING PROTEINS; STRESS GRANULES; REPEAT EXPANSION; LIQUID DROPLETS; P GRANULES; NUCLEOCYTOPLASMIC TRANSPORT; COMPLEX COACERVATION; AGGREGATION-PRONE;

D O I：

10.1016/j.tcb.2018.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.

引用

页码：420 / 435

页数：16

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