Modification of biologically active amides and amines by fluoro-containing heterocycles 10. γ-Carbolines modified by 2-trifluoromethylimidazo-[1,2-a]pyridin-3-ylpropionamide fragments

被引：8
作者：
Bachurin, S. O. [1 ]
Sokolov, V. B. [1 ]
Aksinenko, A. Yu. [1 ]
Epishina, T. A. [1 ]
Goreva, T. V. [1 ]
Grigor'ev, V. V. [1 ]
Zamoiskii, V. L. [1 ]
Gabrel'yan, A. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Physiologically Act Cpds, Chernogolovka 142432, Moscow Region, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2013年 / 62卷 / 11期
基金：
俄罗斯基础研究基金会;
关键词：
gamma-carbolines; substituted 2-trifluoromethylimidazo[1,2-a]pyridines; 3-(1,2,3,4-tetrahydro-5H-pyrido[4,3-b] indol-5-yl)-N-methyl-N-[2-(trifluoromethyl)imidazo[1,2-a]-pyridin-3-yl] propanamides; radioligand binding; COGNITION; DIMEBON;
D O I：
10.1007/s11172-013-0352-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An approach to the modification of biologically active gamma-carbolines by the 2-trifluoromethyl-imidazo[1,2-a] pyridin-3-ylpropionamide fragments was suggested, which consisted of the reaction of N-methyl-N-(2-trifluoromethylimidazo[1,2-a] pyridin-3-yl) prop-2-enamides with gamma-carbolines in the presence of catalytic amounts of cesium fluoride. Method of radioligand binding was used to study effects of the synthesized 3-(1,2,3,4-tetrahydro-5H-pyrido[4,3-b]-indol-5-yl)-N-methyl-N-[2-(trifluoromethyl) imidazo-[1,2-a] pyridin-3-yl] propanamides on the neuronal NMDA-receptors.
引用
收藏
页码：2438 / 2441
页数：4
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