Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer's Disease

被引：29

作者：

Guo, Huifang ^{[1
,2
]}

Zhao, Zhaohua ^{[1
,2
]}

Zhang, Ruisan ^{[1
,2
]}

Chen, Peng ^{[1
,2
]}

Zhang, Xiaohua ^{[1
,2
,3
]}

Cheng, Fan ^{[1
,2
]}

Gou, Xingchun ^{[1
,2
,3
]}

机构：

[1] Xian Med Univ, Shaanxi Key Lab Brain Disorders, 1 Xinwang Rd, Xian 710021, Shaanxi, Peoples R China

[2] Xian Med Univ, Sch Basic Med Sci, 1 Xinwang Rd, Xian 710021, Shaanxi, Peoples R China

[3] Xian Med Univ, Inst Basic & Translat Med, Xian, Shaanxi, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 68卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; amyloid-beta; infiltrating macrophages; Kupffer cells; monocytes; peripheral clearance; SYSTEMIC IMMUNE-SYSTEM; MOUSE MODEL; PRECURSOR PROTEIN; COGNITIVE DEFICITS; MONONUCLEAR-CELLS; BLOOD MONOCYTES; IN-VIVO; BRAIN; NEUROINFLAMMATION; MACROPHAGES;

D O I：

10.3233/JAD-181177

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging societies have high incidence rates of Alzheimer's disease (AD). AD is diagnosed at later disease stages and has a poor prognosis, and effective drugs and treatments for AD are lacking. The molecular mechanism of AD is not clear, and current research focuses primarily on amyloid-beta (A beta) deposition and tau protein hyperphosphorylation. A beta deposition is the most frequently hypothesized initiating factor of AD, and A beta clearance during the pathogenesis of AD may be an optional strategy to suppress AD development. Monocytes play important roles in the peripheral clearance of A beta. Therefore, the present review summarizes our current knowledge of the potential roles of infiltrating macrophages, circulating monocytes, and Kupffer cells in the peripheral clearance of A beta in AD.

引用

页码：1391 / 1400

页数：10

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