Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

被引：14
|
作者：
Park, Ki Tae [1 ]
Yun, Chul-Ho [1 ]
Bae, Chun-Sik [2 ]
Ahn, Taeho [2 ]
机构：
[1] Chonnam Natl Univ, Sch Biol Sci & Technol, Kwangju 500757, South Korea
[2] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2014年 / 76卷 / 08期
关键词：
albumin; diabetes; expression; oxidative stress; streptozotocin; OXIDATIVE STRESS; RADICAL PRODUCTION; URINARY ALBUMIN; EXPRESSION; SERUM; MELLITUS; TISSUES; PROTEIN;
D O I：
10.1292/jvms.13-0631
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We investigated the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) of streptozotocin (STZ)-induced diabetic rats. A specific reduction of albumin was identified by 2-dimensional electrophoresis and mass spectrometry. Decreased albumin content was also confirmed by immunoblotting and quantitative real-time PCR. Since albumin is a major and predominant antioxidant in plasma, the PBMC albumin may also contribute to their antioxidant activity. By measuring the amount of H2O2, lipid peroxidation and the redox form of glutathione, it was found that the production of the oxidative stress was elevated in STZ-diabetic rats compared to that of normal control. We suggest, therefore, that decreased albumin content may lead to the decreased antioxidant activity in the PBMC of type 1 diabetic rats.
引用
收藏
页码：1087 / 1092
页数：6
相关论文
共 50 条
  • [1] Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice
    Ahn, Taeho
    Bae, Chun-Sik
    Yun, Chul-Ho
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2016, 78 (04) : 669 - 674
  • [2] Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats
    Bae, Chun-Sik
    Ahn, Taeho
    VETERINARNI MEDICINA, 2022, 67 (05) : 245 - 256
  • [3] Naringin attenuates liver damage in streptozotocin-induced diabetic rats
    Rodriguez, Valeria
    Plavnik, Luis
    Tolosa de Talamoni, Nori
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 105 : 95 - 102
  • [4] Erectile dysfunction attenuation by naringenin in streptozotocin-induced diabetic rats
    Al-Oanzi, Ziad H.
    JOURNAL OF FOOD BIOCHEMISTRY, 2019, 43 (07)
  • [5] Ischemic colitis of the colon in streptozotocin-induced diabetic rats
    Ozel, Yahya
    Elcioglu, H. Kubra
    Cevikelli, Z. Ayca
    Kudas, Ilyas
    Ahmad, Sarfraz
    Uzun, Hafize
    Topal, Cumhur
    Aktas, Serife
    Kabasakal, Levent
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2018, 439 (1-2) : 87 - 93
  • [6] Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin-Induced Diabetic Rats
    Prasath, Gopalan Sriram
    Subramanian, Sorimuthu Pillai
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2014, 28 (10) : 442 - 449
  • [7] The Preventive Effect of Oxytocin on Retinopathy in Streptozotocin-Induced Diabetic Rats
    Degirmenci, Cumali
    Afrashi, Filiz
    Erbas, Oytun
    Aktug, Huseyin
    Taskiran, Dilek
    TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY, 2019, 49 (02): : 68 - 72
  • [8] Hepatotoxicity of vanadyl sulfate in nondiabetic and streptozotocin-induced diabetic rats
    Samira, Missaoui
    Mounira, Tlili
    Kamel, Kacem
    Yacoubi, Mohamed Tahar
    Ben Rhouma, Khemais
    Sakly, Mohsen
    Tebourbi, Olfa
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2018, 96 (11) : 1076 - 1083
  • [9] Administration of human umbilical cord blood mononuclear cells restores bladder dysfunction in streptozotocin-induced diabetic rats
    Kaya-Sezginer, Ecem
    Yilmaz-Oral, Didem
    Gur, Serap
    LUTS-LOWER URINARY TRACT SYMPTOMS, 2019, 11 (04) : 232 - 240
  • [10] Effects of streptozotocin dosing on the disease state of streptozotocin-induced diabetic rats
    Hasegawa, Y.
    Kishimoto, S.
    Nomura, H.
    Yonezawa, K.
    Inotsume, N.
    Takeuchi, Y.
    Fukushima, S.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2011, 21 (05) : 441 - 444
12345