Fine-Needle Aspiration Biopsy of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Current Ancillary Testing Methods for Determining HPV Status

被引：16

作者：

Bernadt, Cory T. ^{[1
]}

Collins, Brian T. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Campus Box 8118,660 S Euclid Ave, St Louis, MO 63130 USA

来源：

DIAGNOSTIC CYTOPATHOLOGY | 2017年 / 45卷 / 03期

关键词：

human papillomavirus; squamous cell carcinoma; fine needle aspiration; IN-SITU HYBRIDIZATION; HUMAN-PAPILLOMAVIRUS INFECTION; RISK HUMAN-PAPILLOMAVIRUS; LYMPH-NODE METASTASES; OROPHARYNGEAL CANCER; P16; EXPRESSION; SURROGATE MARKER; SEXUAL-BEHAVIOR; UNKNOWN PRIMARY; OCCULT HEAD;

D O I：

10.1002/dc.23668

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to determine the HPV-status has significant prognostic and treatment implications as HPV-related tumors have a more favorable prognosis and response to nonsurgical therapies. While several different ancillary testing methods are available that have proven effective for determining HPV status in FNA specimens from HNSCCs, there is currently no consensus regarding HPV testing in this setting. Diagn. Cytopathol. 2017; 45: 221-229. (C) 2017 Wiley Periodicals, Inc.

引用

页码：221 / 229

页数：9

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