The therapeutic potential of purinergic signalling

被引：104
作者：
Burnstock, Geoffrey [1 ,2 ]
机构：
[1] UCL, Auton Neurosci Ctr, Med Sch, Rowland Hill St, London NW3 2PF, England
[2] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia
来源：
BIOCHEMICAL PHARMACOLOGY | 2018年 / 151卷
关键词：
ATP; CNS; Heart; Liver; Kidney; Skin; ADENOSINE A(2A) RECEPTORS; P2X7; RECEPTOR; P2X(7) RECEPTOR; EXTRACELLULAR ATP; A(2B) RECEPTORS; ANIMAL-MODEL; ACTIVATION; INFLAMMATION; ANTAGONISTS; DISEASE;
D O I：
10.1016/j.bcp.2017.07.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review is focused on the pathophysiology and therapeutic potential of purinergic signalling. A wide range of diseases are considered, including those of the central nervous system, skin, kidney, musculoskeletal, liver gut, lower urinary tract, cardiovascular, airways and reproductive systems, the special senses, infection, diabetes and obesity. Several purinergic drugs are already on the market, including P2Y(12) receptor antagonists for stroke and thrombosis, P2Y(12) receptor agonists for dry eye, and A(1) receptor agonists for supraventricular tachycardia. Clinical trials are underway for the use of P2X3 receptor antagonists for the treatment of chronic cough, visceral pain and hypertension, and many more compounds are being explored for the treatment of other diseases. Most experiments are 'proof of concept' studies on animal or cellular models, which hopefully will lead to further clinical trials. The review summarises the topic, mostly referring to recent review articles. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：157 / 165
页数：9
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