Horsfiequinones A-F, Dimeric Diarylpropanoids from Horsfieldia tetratepala

被引：22
|
作者：
Ma, Qin [1 ]
Min, Kang [2 ]
Li, Hao-Liang [1 ]
Jiang, Jin-He [1 ]
Liu, Ying [1 ]
Zhan, Rui [1 ]
Chen, Ye-Gao [1 ]
机构：
[1] Yunnan Normal Univ, Sch Chem & Chem Engn, Chenggong New Dev Area, Kunming 650500, Yunnan, Peoples R China
[2] Diqing Inst Agr Sci, Shangrila, Yunnan, Peoples R China
来源：
PLANTA MEDICA | 2014年 / 80卷 / 8-9期
关键词：
Horsfieldia tetratepala; Myristicaceae; diarylpropanoid; cytotoxicity; TUMOR-CELL-LINES; STEM BARK; 1,3-DIARYLPROPAN-2-OL; FEASIBILITY; IRYAGHEDHI; SUPERBA; PLANTS;
D O I：
10.1055/s-0034-1368456
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B-F (2-6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B-F (2-6), isolated as enantiomer mixtures with un-equal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 +/- 0.67 to 6.61 +/- 0.08 mu M.
引用
收藏
页码：688 / 694
页数：7
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