Serum lactate as a novel potential biomarker in multiple sclerosis

被引:80
作者
Arnorini, Angela M. [1 ,9 ]
Nociti, Viviana [2 ,3 ]
Petzold, Axel [4 ,5 ]
Gasperini, Claudio
Quartuccio, Esmeralda
Lazzarino, Giacomo [1 ]
Di Pietro, Valentina [6 ]
Belli, Antonio [6 ,7 ]
Signoretti, Stefano
Vagnozzi, Roberto [8 ]
Lazzarino, Giuseppe [9 ]
Tavazzi, Barbara [1 ]
机构
[1] Inst Biochem & Clin Biochem, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy
[3] Fdn Don C Gnocchi, I-20121 Milan, Italy
[4] Vrije Univ Amsterdam Med Ctr, Dept Neurol, NL-1081 HV Amsterdam, Netherlands
[5] S Camillo Forlanini Hosp, Dept Neumsci, I-8700152 Rome, Italy
[6] Univ Birmingham, Sch Clin & Expt Med, Neurotrauma & Neurodegeneret Sect, Coll Med & Dent Sci, Birmingham, W Midlands, England
[7] Queen Elizabeth Hosp, Natl Inst Hlth Res Surg Reconstruct & Microbiol R, Birmingham, W Midlands, England
[8] Univ Roma Tor Vergata, Sect Neurosurg, Dept Biomed & Prevent, I-00133 Rome, Italy
[9] Univ Catania, Div Biochem & Mol Biol, Dept Biol Geol & Environm Sci, Viale A Doria 6, I-95125 Catania, Italy
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2014年 / 1842卷 / 07期
关键词
Clinical disability; Energy penalty; Mitochondrial dysfunction; Multiple sclerosis; Serum lactate; PROTON MR SPECTROSCOPY; WHITE-MATTER; CEREBROSPINAL-FLUID; MITOCHONDRIAL DYSFUNCTION; AXONAL DEGENERATION; ENERGY-METABOLISM; URIC-ACID; EXERCISE; FATIGUE; PLAQUES;
D O I
10.1016/j.bbadis.2014.04.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multiple sclerosis (MS) is a primary inflammatory demyelinating disease associated with a probably secondary progressive neurodegenerative component. Impaired mitochondrial functioning has been hypothesized to drive neurodegeneration and to cause increased anaerobic metabolism in MS. The aim of our multicentre study was to determine whether MS patients had values of circulating lactate different from those of controls. Patients (n = 613) were recruited, assessed for disability and clinically classified (relapsing remitting, secondary progressive, primary progressive) at the Catholic University of Rome, Italy (n = 281), at the MS Centre Amsterdam, The Netherlands (n = 158) and at the S. Camillo Forlanini Hospital, Rome, Italy (n = 174). Serum lactate levels were quantified spectrophotometrically with the analyst being blinded to all clinical information. In patients with MS serum lactate was three times higher (3.04 +/- 1.26 mmol/l) than that of healthy controls (1.09 +/- 025 mmol/l, p < 0.0001) and increased across clinical groups, with higher levels in cases with a progressive than with a relapsing remitting disease course. In addition, there was a linear correlation between serum lactate levels and the expanded disability scale (EDSS) (R-2 = 0.419; p < 0.001). These data support the hypothesis that mitochondrial dysfunction is an important feature in MS and of particular relevance to the neurodegenerative phase of the disease. Measurement of serum lactate in MS might be a relative inexpensive test for longitudinal monitoring of "virtual hypoxia" in MS and also a secondary outcome for treatment trials aimed to improve mitochondrial function in patients with MS. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:1137 / 1143
页数:7
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