The Role of Pericytes in Amyotrophic Lateral Sclerosis

被引:6
作者
Coatti, Giuliana Castello [1 ]
Cavacana, Natale [2 ]
Zatz, Mayana [2 ]
机构
[1] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA
[2] Univ Sao Paulo, Biosci Inst, Human Genome & Stem Cell Res Ctr, Sao Paulo, Brazil
来源
PERICYTE BIOLOGY IN DISEASE | 2019年 / 1147卷
关键词
Amyotrophic lateral sclerosis; Lou Gehrig's disease; Motor neuron; Pericyte; Perivascular cells; Blood-brain barrier; Blood-spinal barrier; Microhemorrhage; SOD1; mice; Pericyte loss; SPINAL CORD BARRIER; BLOOD-BRAIN-BARRIER; CEREBROSPINAL-FLUID; MATRIX METALLOPROTEINASES; ALZHEIMERS-DISEASE; MOTOR-NEURONS; NEURAL CREST; SOD1; MICE; ALS; SERUM;
D O I
10.1007/978-3-030-16908-4_6
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In amyotrophic lateral sclerosis (ALS), motor neurons die selectively. Therefore, initial symptoms that include fasciculation, spasticity, muscle atrophy, and weakness emerge following axons retraction and consequent muscles' denervation. Patients lose the ability to talk and swallow and rely on parenteral nutrition and assisted ventilation to survive. The degeneration caused by ALS is progressive and irreversible. In addition to the autonomous mechanism of neuronal cell death, non-autonomous mechanisms have been proved to be toxic for motor neurons, such as the activation of astrocytes and microglia. Among the cells being studied to unveil these toxic -mechanisms are pericytes, cells that help keep the integrity of the blood-brain barrier and blood-spinal cord barrier. In this chapter, we aim to discuss the role of pericytes in ALS.
引用
收藏
页码:137 / 146
页数:10
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