Altered Immunohistochemical Expression of Mast Cell Tryptase and Chymase in the Pathogenesis of Oral Submucous Fibrosis and Malignant Transformation of the Overlying Epithelium

被引：18

作者：

Yadav, Archana ^{[1
]}

Desai, Rajiv S. ^{[1
]}

Bhuta, Bansari A. ^{[1
]}

Singh, Jatinder S. ^{[1
]}

Mehta, Reema ^{[1
]}

Nehete, Akash P. ^{[1
]}

机构：

[1] Nair Hosp, Coll Dent, Dept Oral Pathol, Bombay, Maharashtra, India

来源：

PLOS ONE | 2014年 / 9卷 / 05期

关键词：

ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; FIBROBLAST PROLIFERATION; COLLAGEN; DENSITY; MYOFIBROBLASTS; INFLAMMATION; RELEVANCE; CLEAVAGE; CANCER;

D O I：

10.1371/journal.pone.0098719

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mast cells (MCs) expressing serine proteases; tryptase and chymase, are associated with fibrosis in various diseases. However, little is known about their involvement in oral submucous fibrosis (OSF). Our goal was to evaluate the role of MC tryptase and chymase in the pathogenesis of OSF and its malignant transformation. Immunohistochemical expression of MC tryptase and chymase was evaluated in 20 cases of OSF, 10 cases of oral squamous cell carcinoma (OSCC) and 10 cases of healthy controls. Subepithelial zone of Stage 1 and 2 while deep zone of Stage 3 and 4 OSF demonstrated increased tryptase positive MCs. OSCC revealed a proportionate increase in tryptase and chymase positive MCs irrespective of areas of distribution. An altered balance in the subepithelial and deep distribution of tryptase and chymase positive MCs play an important role in the pathogenesis of OSF and its malignant transformation.

引用

页数：13

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