Colonization or infection? Why are premature infants and neonates so susceptible?

被引：0

作者：

Haertel, C. ^{[1
]}

Gille, C. ^{[2
]}

Orlikowsky, T. W. ^{[3
]}

机构：

[1] Univ Klinikum Schleswig Holstein, Klin Kinder & Jugendmed, Schleswig Holstein, Germany

[2] Univ Klinikum Tubingen, Abt Neonatol, Tubingen, Germany

[3] Rhein Westfal TH Aachen, Univ Klinikum, Klin Kinder & Jugendmed, Sekt Neonatol Padiatr Intens Med, D-52074 Aachen, Germany

来源：

MONATSSCHRIFT KINDERHEILKUNDE | 2014年 / 162卷 / 05期

关键词：

Newborns; Infant; premature; Infection; Colonization; Immunity; BIRTH-WEIGHT INFANTS; EMPIRICAL ANTIBIOTIC-TREATMENT; FOR-GESTATIONAL-AGE; NOSOCOMIAL INFECTIONS; CORD BLOOD; PRETERM; INNATE; SEPSIS; NEWBORN; RISK;

D O I：

10.1007/s00112-013-2973-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Incidence of sepsis. Out of 650,000 newborn infants per year in Germany approximately 7,000 (1.1%) of term born infants suffer from neonatal sepsis. Approximately 1.3% of neonates belong to the group of very low birth weight (VLBW) infants with a birth weight <1,500 g who have a 10-fold higher risk of sepsis compared to term infants. Discussion. The complex interplay of intrinsic factors (e. g. adaptation of fetal and maternal immune systems, functional immaturity, small anatomical size and loss of protective measures) and exogenous influences (e.g. intensive care measures) is decisive for the vulnerability of preterm and term infants. This review article focuses on these pathophysiological aspects.

引用

页码：394 / +

页数：7

共 50 条

[41] First urinary tract infection in neonates, infants and young children: a comparative study [J].

Theodoros A. Kanellopoulos ;

Christos Salakos ;

Iris Spiliopoulou ;

Aikaterini Ellina ;

Nikoleta M. Nikolakopoulou ;

Dimitris A. Papanastasiou .

Pediatric Nephrology, 2006, 21 :1131-1137

[42] First urinary tract infection in neonates, infants and young children: a comparative study [J].

Kanellopoulos, Theodoros A. ;

Salakos, Christos ;

Spiliopoulou, Iris ;

Ellina, Aikaterini ;

Nikolakopoulou, Nikoleta M. ;

Papanastasiou, Dimitris A. .

PEDIATRIC NEPHROLOGY, 2006, 21 (08) :1131-1137

[43] Role of antimicrobial applications to the umbilical cord in neonates to prevent bacterial colonization and infection: a review of the evidence [J].

Mullany, LC ;

Darmstadt, GL ;

Tielsch, JM .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (11) :996-1002

[44] Strain-resolved metagenomic analysis of the gut as a reservoir for bloodstream infection pathogens among premature infants in Singapore [J].

Heston, Sarah M. ;

Lim, Charis Shu En ;

Ong, Chengsi ;

Chua, Mei Chien ;

Kelly, Matthew S. ;

Yeo, Kee Thai .

GUT PATHOGENS, 2023, 15 (01)

[45] Postnatally acquired cytomegalovirus infection in extremely premature infants: how best to manage? [J].

Kadambari, Seilesh ;

Whittaker, Elizabeth ;

Lyall, Hermione .

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2020, 105 (03) :F334-F339

[46] The Association of Intraventricular Hemorrhage and Acute Kidney Injury in Premature Infants from the Assessment of the Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) Study [J].

Stoops, Christine ;

Boohaker, Louis ;

Sims, Brian ;

Griffin, Russell ;

Selewski, David T. ;

Askenazi, David ;

Ambalavanan, Namasivayam ;

Sarkar, Subrata ;

Kent, Alison ;

Fletcher, Jeffery .

NEONATOLOGY, 2019, 116 (04) :321-330

[47] Surveillance for Colonization, Transmission, and Infection With Methicillin-Susceptible Staphylococcus aureus in a Neonatal Intensive Care Unit [J].

Nurjadi, Dennis ;

Eichel, Vanessa M. ;

Tabatabai, Patrik ;

Klein, Sabrina ;

Last, Katharina ;

Mutters, Nico T. ;

Poschl, Johannes ;

Zanger, Philipp ;

Heeg, Klaus ;

Boutin, Sebastien .

JAMA NETWORK OPEN, 2021, 4 (09) :E2124938

[48] Histological chorioamnionitis - implication for bacterial colonization, laboratory markers of infection, and early onset sepsis in very-low-birth-weight neonates [J].

Lee, Shing Yan Robert ;

Leung, Chi Wai .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2012, 25 (04) :364-368

[49] Risk factors and clinical analysis of peripherally inserted central catheter-related fungal colonization in premature infants [J].

Zhang, Lingping ;

Yang, Liu ;

Dong, Wenbin ;

Liu, Xingling ;

Lei, Xiaoping ;

Zhang, Lianyu .

SCIENTIFIC REPORTS, 2021, 11 (01)

[50] Bone and joint infection complicated with sepsis in neonates and infants under three months of age [J].

Liu, Yao ;

Zhao, Kai ;

Liu, Ya ;

Li, Meng-Xia ;

Yu, Min ;

Zhu, Lun-Qing ;

Wang, Xiao-Dong .

JORNAL DE PEDIATRIA, 2024, 100 (02) :156-162

← 1 2 3 4 5 →