Colonization or infection? Why are premature infants and neonates so susceptible?

被引：0

作者：

Haertel, C. ^{[1
]}

Gille, C. ^{[2
]}

Orlikowsky, T. W. ^{[3
]}

机构：

[1] Univ Klinikum Schleswig Holstein, Klin Kinder & Jugendmed, Schleswig Holstein, Germany

[2] Univ Klinikum Tubingen, Abt Neonatol, Tubingen, Germany

[3] Rhein Westfal TH Aachen, Univ Klinikum, Klin Kinder & Jugendmed, Sekt Neonatol Padiatr Intens Med, D-52074 Aachen, Germany

来源：

MONATSSCHRIFT KINDERHEILKUNDE | 2014年 / 162卷 / 05期

关键词：

Newborns; Infant; premature; Infection; Colonization; Immunity; BIRTH-WEIGHT INFANTS; EMPIRICAL ANTIBIOTIC-TREATMENT; FOR-GESTATIONAL-AGE; NOSOCOMIAL INFECTIONS; CORD BLOOD; PRETERM; INNATE; SEPSIS; NEWBORN; RISK;

D O I：

10.1007/s00112-013-2973-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Incidence of sepsis. Out of 650,000 newborn infants per year in Germany approximately 7,000 (1.1%) of term born infants suffer from neonatal sepsis. Approximately 1.3% of neonates belong to the group of very low birth weight (VLBW) infants with a birth weight <1,500 g who have a 10-fold higher risk of sepsis compared to term infants. Discussion. The complex interplay of intrinsic factors (e. g. adaptation of fetal and maternal immune systems, functional immaturity, small anatomical size and loss of protective measures) and exogenous influences (e.g. intensive care measures) is decisive for the vulnerability of preterm and term infants. This review article focuses on these pathophysiological aspects.

引用

页码：394 / +

页数：7

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