Visible-light-mediated photoredox minisci C-H alkylation with alkyl boronic acids using molecular oxygen as an oxidant

被引：58

作者：

Dong, Jianyang ^{[1
]}

Yue, Fuyang ^{[1
]}

Song, Hongjian ^{[1
]}

Liu, Yuxiu ^{[1
]}

Wang, Qingmin ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 83期

基金：

中国国家自然科学基金;

关键词：

N-HETEROARENES; ELECTRON-TRANSFER; FUNCTIONALIZATION; ARYLATION; ACTIVATION; CATALYSIS; HETEROCYCLES; ALCOHOLS; SUBSTITUTIONS; ENABLES;

D O I：

10.1039/d0cc05946c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a protocol for direct visible-light-mediated Minisci C-H alkylation reactions of heteroarenes with alkyl boronic acids using molecular oxygen as the sole oxidant. This mild protocol uses an inexpensive, green oxidant; permits efficient functionalization of various N-heteroarenes with a broad range of primary and secondary alkyl boronic acids; and is scalable to the gram level. We demonstrated the practicality and sustainability of the protocol by preparing or functionalizing several pharmaceuticals and natural products.

引用

页码：12652 / 12655

页数：4

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