The core structure of the lipopolysaccharide from the causative agent of plague, Yersinia pestis

被引：51

作者：

Vinogradov, EV

Lindner, B

Kocharova, NA

Senchenkova, SN

Shashkov, AS

Knirel, YA

Holst, O

Gremyakova, TA

Shaikhutdinova, RZ

Anisimov, AP

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

[2] Res Ctr Borstel, Ctr Med & Biosci, D-23845 Borstel, Germany

[3] State Res Ctr Appl Microbiol, Obolensk 142279, Moscow Region, Russia

来源：

CARBOHYDRATE RESEARCH | 2002年 / 337卷 / 09期

关键词：

lipopolysaccharide; Yersinia pestis; core structure;

D O I：

10.1016/S0008-6215(02)00074-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rough-type lipopolysaccharide (LPS) of the plague pathogen, Yersinia pestis, was studied after mild-acid and. strong-alkaline degradations by chemical analyses, NMR spectroscopy and electrospray-ionization mass spectrometry, and the following structure of the core region was determined: [GRAPHICS] where L-alpha-D-Hep stands for L-glycero-alpha-D-manno-heptose, Sug1 for either 3-deoxy-alpha-D-manno-oct-2-ulosonic acid (alpha-Kdo) or D-glycero-alpha-D-talo-oct-2-ulosonic acid (alpha-Ko), and Sug2 for either beta-D-galactose or D-glycero-alpha-D-manno-heptose. A minority of the LPS molecules lacks GlcNAc. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：775 / 777

页数：3