The core structure of the lipopolysaccharide from the causative agent of plague, Yersinia pestis

被引：51
作者：
Vinogradov, EV
Lindner, B
Kocharova, NA
Senchenkova, SN
Shashkov, AS
Knirel, YA
Holst, O
Gremyakova, TA
Shaikhutdinova, RZ
Anisimov, AP
机构：
[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia
[2] Res Ctr Borstel, Ctr Med & Biosci, D-23845 Borstel, Germany
[3] State Res Ctr Appl Microbiol, Obolensk 142279, Moscow Region, Russia
来源：
CARBOHYDRATE RESEARCH | 2002年 / 337卷 / 09期
关键词：
lipopolysaccharide; Yersinia pestis; core structure;
D O I：
10.1016/S0008-6215(02)00074-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The rough-type lipopolysaccharide (LPS) of the plague pathogen, Yersinia pestis, was studied after mild-acid and. strong-alkaline degradations by chemical analyses, NMR spectroscopy and electrospray-ionization mass spectrometry, and the following structure of the core region was determined: [GRAPHICS] where L-alpha-D-Hep stands for L-glycero-alpha-D-manno-heptose, Sug1 for either 3-deoxy-alpha-D-manno-oct-2-ulosonic acid (alpha-Kdo) or D-glycero-alpha-D-talo-oct-2-ulosonic acid (alpha-Ko), and Sug2 for either beta-D-galactose or D-glycero-alpha-D-manno-heptose. A minority of the LPS molecules lacks GlcNAc. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：775 / 777
页数：3
相关论文
共 12 条
[1]  
[Anonymous], 1974, ADV CARBOHYD CHEM BI
[2]   A SIMPLE AND RAPID METHOD FOR THE PERMETHYLATION OF CARBOHYDRATES [J].
CIUCANU, I ;
KEREK, F .
CARBOHYDRATE RESEARCH, 1984, 131 (02) :209-217
[3]  
DOMARADSKII IV, 1993, PLAGUE CONT STATE AS
[4]   Isolation and characterisation of disodium (4-amino-4-deoxy-β-L-arabinopyranosyl)-(1→8)-(D-glycero-α-D-talo-oct-2-ulopyranosylonate)-(2→4)-(methyl 3-deoxy-D-manno-oct-2-ulopyranosid)onate from the lipopolysaccharide of Burkholderia cepacia [J].
Isshiki, Y ;
Kawahara, K ;
Zähringer, U .
CARBOHYDRATE RESEARCH, 1998, 313 (01) :21-27
[5]  
Jansson P.-E., 1976, CHEM COMMUN, V8, P1
[6]   The structure of the carbohydrate backbone of the core-lipid A region of the lipopolysaccharide from a clinical isolate of Yersinia enterocolitica 0:9 [J].
Müller-Loennies, S ;
Rund, S ;
Ervelä, E ;
Skurnik, M ;
Holst, O .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 261 (01) :19-24
[7]   Isolation and structural characterization of an R-form lipopolysaccharide from Yersinia enterocolitica serotype O:8 [J].
Oertelt, C ;
Lindner, B ;
Skurnik, M ;
Holst, O .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (03) :554-564
[8]   Yersinia pestis - Etiologic agent of plague [J].
Perry, RD ;
Fetherston, JD .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (01) :35-+
[9]   Characterization of the lipopolysaccharide of Yersinia pestis [J].
Prior, JL ;
Hitchen, PG ;
Williamson, ED ;
Reason, AJ ;
Morris, HR ;
Dell, A ;
Wren, BW ;
Titball, RW .
MICROBIAL PATHOGENESIS, 2001, 30 (02) :49-57
[10]   Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y-pseudotuberculosis serotype O:1b [J].
Skurnik, M ;
Peippo, A ;
Ervelä, E .
MOLECULAR MICROBIOLOGY, 2000, 37 (02) :316-330
12