Assembly and structure of protein phosphatase 2A

被引：57
作者：
Shi YiGong [1 ]
机构：
[1] Tsinghua Univ, Sch Med, Dept Biol Sci & Biotechnol, Struct Biol Ctr, Beijing 100084, Peoples R China
来源：
SCIENCE IN CHINA SERIES C-LIFE SCIENCES | 2009年 / 52卷 / 02期
关键词：
protein phosphorylation; dephosphorylation; PP2A; structure; mechanism; TERMINAL LEUCINE RESIDUE; PP2A CATALYTIC SUBUNIT; SMALL-T-ANTIGEN; RABBIT SKELETAL-MUSCLE; REGULATORY B-SUBUNITS; MIDDLE TUMOR-ANTIGEN; A-SUBUNIT; CRYSTAL-STRUCTURE; BOVINE BRAIN; METHYL ESTERIFICATION;
D O I：
10.1007/s11427-009-0018-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Protein phosphatase 2A (PP2A) represents a conserved family of important protein serine/threonine phosphatases in species ranging from yeast to human. The PP2A core enzyme comprises a scaffold subunit and a catalytic subunit. The heterotrimeric PP2A holoenzyme consists of the core enzyme and a variable regulatory subunit. The catalytic subunit of PP2A is subject to reversible methylation, mediated by two conserved enzymes. Both the PP2A core and holoenzymes are regulated through interaction with a large number of cellular cofactors. Recent biochemical and structural investigation reveals critical insights into the assembly and function of the PP2A core enzyme as well as two families of holoenzyme. This review focuses on the molecular mechanisms revealed by these latest advances.
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页码：135 / 146
页数：12
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