Practical Approach for Asymmetric Hydroxyamination of Aldehydes with in Situ Generated Nitrosocarbonyl Compounds: Application to One-Pot Synthesis of Chiral Allylamines

被引：37

作者：

Kano, Taichi ^{[1
]}

Shirozu, Fumitaka ^{[1
]}

Maruoka, Keiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 05期

关键词：

ELECTROPHILIC ALPHA-AMINATION; DIPHENYLPROLINOL SILYL ETHERS; CATALYZED AEROBIC OXIDATION; DIELS-ALDER REACTION; NITROSO ENE REACTION; ENANTIOSELECTIVE HYDROXYAMINATION; HYDROXAMIC ACIDS; AMINO ALCOHOLS; ALDOL REACTION; EFFICIENT;

D O I：

10.1021/ol5000742

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.

引用

页码：1530 / 1532

页数：3

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