The antinociceptive effect of tramadol on a model of neuropathic pain in rats

被引：47

作者：

Apaydin, S ^{[1
]}

Uyar, M

Karabay, NU

Erhan, E

Yegul, I

Tuglular, I

机构：

[1] Ege Univ, Ctr Drug R&D & Pharmacokinet Applicat, TR-35100 Izmir, Turkey

[2] Ege Univ, Fac Med, Dept Algol, TR-35100 Izmir, Turkey

[3] Ege Univ, Fac Sci, Dept Biol, TR-35100 Izmir, Turkey

来源：

LIFE SCIENCES | 2000年 / 66卷 / 17期

关键词：

tramadol; neuropathic pain; sciatic nerve ligation;

D O I：

10.1016/S0024-3205(00)00482-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The antinociceptive activity of tramadol was investigated on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. Despite the analgesic activity of tramadol was clearly established in motor and sensory responses of the nociceptive system in rats, the effect of this atypical opioid on experimental neuropathic pain models is not investigated. The intraperitoneally injected tramadol (2.5, 5 and 10 mg / kg) produced a potent and dose-dependent antinociceptive effect on both lesioned and non-lesioned hind paws. However, the analgesic effect on the lesioned paw was significantly more potent than the non-lesioned paw. This effect was partially antagonized by intraperitoneally administered naloxone (0.1 mg / kg) suggesting an additional non-opioid mechanism. Our results suggest that tramadol may be useful for the alleviation of some symptoms in peripheral neuropathic conditions.

引用

页码：1627 / 1637

页数：11

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