Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms

被引：57
作者：
Zhang, Xiaoran [1 ]
Ares, William J. [1 ]
Taussky, Philipp [2 ]
Ducruet, Andrew F. [3 ]
Grandhi, Ramesh [2 ]
机构：
[1] Univ Pittsburgh, Med Ctr, Dept Neurol Surg, Pittsburgh, PA USA
[2] Univ Utah, Sch Med, Dept Neurosurg, Salt Lake City, UT USA
[3] Barrow Neurol Inst, Dept Neurol Surg, Phoenix, AZ 85013 USA
来源：
NEUROSURGICAL FOCUS | 2019年 / 47卷 / 01期
关键词：
matrix metalloproteinase; intracranial aneurysm; extracellular matrix; vascular remodeling; inflammation; SMOOTH-MUSCLE-CELLS; ABDOMINAL AORTIC-ANEURYSM; CEREBRAL ANEURYSM; TISSUE INHIBITORS; INFLAMMATORY RESPONSE; EXTRACELLULAR-MATRIX; OXIDATIVE STRESS; PLASMA-LEVELS; UP-REGULATION; SUDDEN-DEATH;
D O I：
10.3171/2019.4.FOCUS19214
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Intracranial aneurysms (IAs) are a result of complex interactions between biochemical and mechanical forces and can lead to significant morbidity if they rupture and cause subarachnoid hemorrhage. This review explores the role of matrix metalloproteinases (MMPs) in the pathogenesis and progression of IAs. In addition to providing a review of the normal function of MMPs, it is intended to explore the interaction between inflammation and abnormal blood flow and the resultant pathological vascular remodeling processes seen in the development and rupture of lAs. Also reviewed is the potential for the use of MMPs as a diagnostic tool for assessment of aneurysm development and progression.
引用
收藏
页数：7
相关论文
共 50 条
[31]   Molecular Mechanisms of the Formation and Progression of Intracranial Aneurysms [J].
Kataoka, Hiroharu .
NEUROLOGIA MEDICO-CHIRURGICA, 2015, 55 (03) :214-229
[32]   New Insights into the Role of Matrix Metalloproteinases in Preeclampsia [J].
Espino Y Sosa, Salvador ;
Flores-Pliego, Arturo ;
Espejel-Nunez, Aurora ;
Medina-Bastidas, Diana ;
Vadillo-Ortega, Felipe ;
Zaga-Clavellina, Veronica ;
Estrada-Gutierrez, Guadalupe .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (07)
[33]   Matrix metalloproteinases as possible biomarkers of obstructive sleep apnea severity - A systematic review [J].
Franczak, Aleksandra ;
Bil-Lula, Iwona ;
Sawicki, Grzegorz ;
Fenton, Mark ;
Ayas, Najib ;
Skomro, Robert .
SLEEP MEDICINE REVIEWS, 2019, 46 :9-16
[34]   Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis? [J].
Al-Dasooqi, Noor ;
Gibson, Rachel J. ;
Bowen, Joanne M. ;
Keefe, Dorothy M. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 64 (01) :1-9
[35]   The Role of Inflammation and Myeloperoxidase-Related Oxidative Stress in the Pathogenesis of Genetically Triggered Thoracic Aortic Aneurysms [J].
Malecki, Cassandra ;
Hambly, Brett D. ;
Jeremy, Richmond W. ;
Robertson, Elizabeth N. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (20) :1-22
[36]   Matrix Metalloproteinases in Respiratory Diseases: From Pathogenesis to Potential Clinical Implications [J].
Oikonomidi, Smaragda ;
Kostikas, Konstantinos ;
Tsilioni, Irene ;
Tanou, Kalliopi ;
Gourgoulianis, Konstantinos I. ;
Kiropoulos, Theodoros S. .
CURRENT MEDICINAL CHEMISTRY, 2009, 16 (10) :1214-1228
[37]   Role of Matrix Metalloproteinases in Animals [J].
Asawakarn, Sariya ;
Asawakarn, Tanong .
THAI JOURNAL OF VETERINARY MEDICINE, 2012, 42 (02) :137-142
[38]   Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis [J].
Sabir, Usman ;
Gu, Hong-mei ;
Zhang, Da-Wei .
PHYTOTHERAPY RESEARCH, 2023, 37 (11) :4932-4962
[39]   The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) [J].
Balkowiec, Magdalenia ;
Maksym, Radoslaw B. ;
Wlodarski, Pawel K. .
MOLECULAR MEDICINE REPORTS, 2018, 18 (03) :3123-3136
[40]   Targeting Matrix Metalloproteinases for Diabetic Retinopathy: The Way Ahead? [J].
Solanki, Ankita ;
Bhatt, Lokesh K. ;
Johnston, Thomas P. ;
Prabhavalkar, Kedar S. .
CURRENT PROTEIN & PEPTIDE SCIENCE, 2019, 20 (04) :324-333
12345