Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms

被引：59
|
作者：
Zhang, Xiaoran [1 ]
Ares, William J. [1 ]
Taussky, Philipp [2 ]
Ducruet, Andrew F. [3 ]
Grandhi, Ramesh [2 ]
机构：
[1] Univ Pittsburgh, Med Ctr, Dept Neurol Surg, Pittsburgh, PA USA
[2] Univ Utah, Sch Med, Dept Neurosurg, Salt Lake City, UT USA
[3] Barrow Neurol Inst, Dept Neurol Surg, Phoenix, AZ 85013 USA
来源：
NEUROSURGICAL FOCUS | 2019年 / 47卷 / 01期
关键词：
matrix metalloproteinase; intracranial aneurysm; extracellular matrix; vascular remodeling; inflammation; SMOOTH-MUSCLE-CELLS; ABDOMINAL AORTIC-ANEURYSM; CEREBRAL ANEURYSM; TISSUE INHIBITORS; INFLAMMATORY RESPONSE; EXTRACELLULAR-MATRIX; OXIDATIVE STRESS; PLASMA-LEVELS; UP-REGULATION; SUDDEN-DEATH;
D O I：
10.3171/2019.4.FOCUS19214
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Intracranial aneurysms (IAs) are a result of complex interactions between biochemical and mechanical forces and can lead to significant morbidity if they rupture and cause subarachnoid hemorrhage. This review explores the role of matrix metalloproteinases (MMPs) in the pathogenesis and progression of IAs. In addition to providing a review of the normal function of MMPs, it is intended to explore the interaction between inflammation and abnormal blood flow and the resultant pathological vascular remodeling processes seen in the development and rupture of lAs. Also reviewed is the potential for the use of MMPs as a diagnostic tool for assessment of aneurysm development and progression.
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页数：7
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