Screening of Fabry Disease in Patients with Chest Pain Without Obstructive Coronary Artery Disease

被引：1

作者：

Hernandez-Hernandez, Aitor ^{[1
]}

Diez-Lopez, Carles ^{[2
]}

Azevedo, Olga ^{[3
]}

Palomino-Doza, Julian ^{[4
]}

Alfonso, Fernando ^{[5
]}

Fuentes-Canamero, Maria Eugenia ^{[6
]}

Mogollon Jimenez, Maria Victoria ^{[7
]}

Casanova Rodriguez, Carlos ^{[8
]}

Ruz, Aurora ^{[9
]}

Tiron, Coloma ^{[10
]}

Climent, Vicente ^{[11
]}

Garcia-Pavia, Pablo ^{[1
]}

机构：

[1] Hosp Univ Puerta Hierro Majadahonda, CIBERCV, Manuel de Falla 2, Madrid 28222, Spain

[2] Hosp Univ Bellvitge, Barcelona, Spain

[3] Hosp Senhora Oliveira, Guimaraes, Portugal

[4] Hosp Univ 12 Octubre, CIBERCV, Madrid, Spain

[5] Hosp Univ La Princesa, Madrid, Spain

[6] Hosp Univ Badajoz, Badajoz, Spain

[7] Complejo Hosp Univ Caceres, Caceres, Spain

[8] Hosp Univ Infanta Sofia, Madrid, Spain

[9] Hosp La Serrania, Ronda, Spain

[10] Hosp Univ Dr Josep Trueta, CIBERCV, Girona, Spain

[11] Hosp Gen Univ Alicante, Alicante, Spain

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2021年 / 14卷 / 05期

关键词：

Fabry disease; Chest pain; Cardiovascular disease; Angina;

D O I：

10.1007/s12265-020-10097-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Identification of Anderson-Fabry disease (AFD) in cardiac patients has been restricted so far to patients with left ventricular hypertrophy. Coronary microvascular dysfunction has been described in AFD with and without cardiac hypertrophy and may represent the only manifestation in AFD patients, offering a possible earlier diagnosis. We studied the prevalence of AFD in 663 patients with chest pain with normal or non-obstructive coronary arteries. The overall prevalence of AFD in this cohort was only 0.15% (1/663). AFD is not a frequent cause of chest pain without obstructive coronary artery disease and screening efforts should not be conducted in this patient population.

引用

页码：948 / 950

页数：3

共 5 条

[1] Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease [J].

Kitani, Yuya ;

Nakagawa, Naoki ;

Sakamoto, Naka ;

Takeuchi, Toshiharu ;

Takahashi, Fumihiko ;

Momosaki, Ken ;

Nakamura, Kimitoshi ;

Endo, Fumio ;

Maruyama, Hiroki ;

Hasebe, Naoyuki .

CIRCULATION JOURNAL, 2019, 83 (02) :481-+

[2] Negative screening of Fabry disease in patients with conduction disorders requiring a pacemaker [J].

Lopez-Sainz, Angela ;

Climent, Vicente ;

Ripoll-Vera, Tomas ;

Angeles Espinosa, Maria ;

Barriales-Villa, Roberto ;

Navarro, Marina ;

Limeres, Javier ;

Domingo, Diana ;

Kasper, David C. ;

Garcia-Pavia, Pablo .

ORPHANET JOURNAL OF RARE DISEASES, 2019, 14

[3] Fabry disease revisited: Management and treatment recommendations for adult patients [J].

Ortiz, Alberto ;

Germain, Dominique P. ;

Desnick, Robert J. ;

Politei, Juan ;

Mauer, Michael ;

Burlina, Alessandro ;

Eng, Christine ;

Hopkin, Robert J. ;

Laney, Dawn ;

Linhart, Ales ;

Waldek, Stephen ;

Wallace, Eric ;

Weidemann, Frank ;

Wilcox, William R. .

MOLECULAR GENETICS AND METABOLISM, 2018, 123 (04) :416-427

[4] Time delays in the diagnosis and treatment of Fabry disease [J].

Reisin, Ricardo ;

Perrin, Amandine ;

Garcia-Pavia, Pablo .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2017, 71 (01)

[5] Coronary microvascular dysfunction is an early feature of cardiac involvement in patients with AndersonFabry disease [J].

Tomberli, Benedetta ;

Cecchi, Franco ;

Sciagra, Roberto ;

Berti, Valentina ;

Lisi, Francesca ;

Torricelli, Francesca ;

Morrone, Amelia ;

Castelli, Gabriele ;

Yacoub, Magdi H. ;

Olivotto, Iacopo .

EUROPEAN JOURNAL OF HEART FAILURE, 2013, 15 (12) :1363-1373

← 1 →