The failure of rodent carcinogenesis as a model for Man

被引：6

作者：

Berry, Colin ^{[1
]}

机构：

[1] Queen Mary London, Mile End Rd, London E1 4NS, England

来源：

TOXICOLOGY RESEARCH | 2018年 / 7卷 / 04期

关键词：

STEM-CELL DIVISIONS; CANCER-RISK; GENES; TOXICOLOGY; MUTATIONS; SAFETY; BRCA2;

D O I：

10.1039/c7tx00283a

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Recent advances in our understanding of the process of carcinogenesis in Man have required revision of our thinking about the classical initiation/promotion sequence; understanding must now encompass the roles of both genetic and epigenetic change, realisation of the importance of the variable genetic backgrounds of the tumour bearers in any group and an understanding of the importance of random genetic events over time. The behavior of tumours, once established, is more complex than has been thought. Current views of the processes involved are not modelled in toxicity testing programmes.

引用

页码：553 / 557

页数：5

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