Wnt Signaling in Renal Cell Carcinoma

被引：80

作者：

Xu, Qi ^{[1
]}

Krause, Mirja ^{[1
]}

Samoylenko, Anatoly ^{[1
]}

Vainio, Seppo ^{[1
]}

机构：

[1] Univ Oulu, Oulu Ctr Cell Matrix Res, Bioctr Oulu, Fac Biochem & Mol Med, POB 5000, FI-90014 Oulu, Finland

来源：

CANCERS | 2016年 / 8卷 / 06期

基金：

芬兰科学院;

关键词：

renal cell carcinoma; Wnt signaling pathway; therapeutic target; development; ANTICANCER DRUG TARGETS; BETA-CATENIN; KIDNEY DEVELOPMENT; TUMOR-SUPPRESSOR; ANTAGONIST GENE; STEM-CELL; EXPRESSION; CANCER; PATHWAY; GROWTH;

D O I：

10.3390/cancers8060057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers. Due to poor diagnosis, high resistance to the systemic therapies and the fact that most RCC cases occur sporadically, current research switched its focus on studying the molecular mechanisms underlying RCC. The aim is the discovery of new effective and less toxic anti-cancer drugs and novel diagnostic markers. Besides the PI3K/Akt/mTOR, HGF/Met and VHL/hypoxia cellular signaling pathways, the involvement of the Wnt/beta-catenin pathway in RCC is commonly studied. Wnt signaling and its targeted genes are known to actively participate in different biological processes during embryonic development and renal cancer. Recently, studies have shown that targeting this pathway by alternating/inhibiting its intracellular signal transduction can reduce cancer cells viability and inhibit their growth. The targets and drugs identified show promising potential to serve as novel RCC therapeutics and prognostic markers. This review aims to summarize the current status quo regarding recent research on RCC focusing on the involvement of the Wnt/beta-catenin pathway and how its understanding could facilitate the identification of potential therapeutic targets, new drugs and diagnostic biomarkers.

引用

页数：14

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[21] Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling [J].

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[23] CORO6 Promotes Cell Growth and Invasion of Clear Cell Renal Cell Carcinoma via Activation of WNT Signaling [J].

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[24] VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma [J].

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[25] Noncanonical Wnt Signaling in Vertebrate Development, Stem Cells, and Diseases [J].

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[26] Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma [J].

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[27] RUNX2 interacts with SCD1 and activates Wnt/β-catenin signaling pathway to promote the progression of clear cell renal cell carcinoma [J].

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[28] Wnt and planar cell polarity signaling in cystic renal disease [J].

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[29] Research progress of the Hippo signaling pathway in renal cell carcinoma [J].

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Shi, Xiaolei ;

Wang, Linhui .

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[30] Effects of TGF-β signaling in clear cell renal cell carcinoma cells [J].

Bostrom, Anna-Karin ;

Lindgren, David ;

Johansson, Martin E. ;

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