High Frequency of Clinically Significant Mutations after First-Line Generic Highly Active Antiretroviral Therapy Failure: Implications for Second-Line Options in Resource-Limited Settings

被引：56

作者：

Kumarasamy, N. ^{[1
]}

Madhavan, Vidya ^{[1
]}

Venkatesh, Kartik K. ^{[3
]}

Saravanan, S. ^{[1
]}

Kantor, Rami ^{[3
]}

Balakrishnan, P. ^{[1
]}

Devaleenal, Bella ^{[1
]}

Poongulali, S. ^{[1
]}

Yepthomi, Tokugha ^{[1
]}

Solomon, Suniti ^{[1
]}

Mayer, Kenneth H. ^{[3
]}

Benson, Constance ^{[2
]}

Schooley, Robert ^{[2
]}

机构：

[1] YRG Ctr AIDS Res & Educ, Voluntary Hlth Serv, Madras 600013, Tamil Nadu, India

[2] Univ Calif San Diego, San Diego, CA 92103 USA

[3] Brown Univ, Miriam Hosp, Sch Med, Providence, RI USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 02期

关键词：

HIV-1; DRUG-RESISTANCE; SOUTH-AFRICA; REGIMEN; INDIVIDUALS; COMBINATION; VIREMIA; ADULTS;

D O I：

10.1086/600044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Continuation of failed highly active antiretroviral therapy regimens can lead to the accumulation of mutations that may limit options for second-line treatment. We studied the pattern of drug resistance mutations among 138 Indian patients who experienced failure of nonnucleotide reverse-transcriptase-containing first-line highly active antiretroviral therapy. This study demonstrates a high frequency of drug resistance mutations in human immunodeficiency virus-infected Indians who experience immunologic treatment failure and suggests the need for viral load monitoring.

引用

页码：306 / 309

页数：4

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