Total synthesis of norzoanthamine

被引：202

作者：

Miyashita, M ^{[1
]}

Sasaki, M ^{[1
]}

Hattori, I ^{[1
]}

Sakai, M ^{[1
]}

Tanino, K ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Sci, Div Chem, Sapporo, Hokkaido 0600810, Japan

来源：

SCIENCE | 2004年 / 305卷 / 5683期

关键词：

D O I：

10.1126/science.1098851

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Norzoanthamine, an alkaloid isolated from Zoanthus sp., can suppress the loss of bone weight and strength in ovariectomized mice. Norzoanthamine derivatives can also strongly inhibit the growth of P-388 murine leukemia cell lines and human platelet aggregation. However, norzoanthamine's densely functionalized complex stereostructure and scarce availability from natural sources have proved a synthetic challenge. We report the stereoselective total synthesis of norzoanthamine in 41 steps, with an overall yield of 3.5% ( an average of 92% yield each step).

引用

页码：495 / 499

页数：5

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