Preparation and characterization of microporous fibers for sample preparation and LC-MS determination of drugs

被引：21

作者：

Buszewski, Boguslaw ^{[1
]}

Nowaczyk, Jacek ^{[2
]}

Ligor, Tomasz ^{[1
]}

Olszowy, Pawel ^{[2
]}

Ligor, Magdalena ^{[1
]}

Wasiniak, Bartlomiej ^{[1
]}

Miekisch, Wolfram ^{[3
]}

Schubert, Jochen K. ^{[3
]}

Amann, Anton ^{[4
]}

机构：

[1] Nicholas Copernicus Univ, Fac Chem, Chair Environm Chem & Bioanalyt, PL-87100 Torun, Poland

[2] Nicholas Copernicus Univ, Fac Chem, Chair Phys Chem & Physicochem Polymers, PL-87100 Torun, Poland

[3] Univ Rostock, Fac Med, Dept Anesthesiol & Intens Care, Rostock, Germany

[4] Innsbruck Med Univ, Dept Anesthesiol & Crit Care Med, Innsbruck, Austria

来源：

JOURNAL OF SEPARATION SCIENCE | 2009年 / 32卷 / 14期

关键词：

Cardiovascular drugs; Electropolymerization; HPLC-MS; Polypyrrole; Solid phase microextraction; SOLID-PHASE MICROEXTRACTION; POLYPYRROLE; EXTRACTION; FILMS; CHROMATOGRAPHY; SYSTEMS; WATER;

D O I：

10.1002/jssc.200900094

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of this study was the preparation of polypyrrole (PPy) fibers for solid phase microextraction (SPME). PPy coatings were obtained during the electrochemical polymerization process. The utility of various metal wires (Fe, Cu, Ag, Cu/Ag, kanthal and medical stainless steel) as a support for polymers was compared. Various experimental conditions of the synthesis process such as scan rate, voltage limits and number of scans and deposition time were applied. The average polymer thickness was in the range of 7-125 mu m and its weight was in the scope of 0.65-5.6 mg. Different techniques, mainly elemental analysis, Fourier transform infrared spectroscopy, microscopy, and chromatography were performed for the characterization of obtained fibers with microporous structure. The extraction efficiency of cardiovascular drugs (metoprolol, propranolol, oxprenolol, propafenone and mexiletine) by means of fibers was tested. The concentration of mentioned compounds in standard solution was in the span of 10-150 ng/mL. LC-MS was employed for determination of drugs in desorption solution. LODs varied from 0.013 to 1.51 ng/mL for metoprolol and mexiletine respectively. The repeatability of extraction was obtained with the RSD values lower than 10%.

引用

页码：2448 / 2454

页数：7

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