Systematics of relative biological effectiveness measurements for proton radiation along the spread out Bragg peak: experimental validation of the local effect model

被引:46
作者
Gruen, Rebecca [1 ]
Friedrich, Thomas [1 ]
Kraemer, Michael [1 ]
Scholz, Michael [1 ]
机构
[1] GSI Helmholtzzentrum Schwerionenforsch, Dept Biophys, Darmstadt, Germany
关键词
relative biological effectiveness (RBE); local effect model (LEM); spread out Bragg peak (SOBP); linear energy transfer (LET); cell survival measurements; in vivo measurements; proton radiotherapy; NATIONAL-CANCER-CENTER; CARBON-ION-BEAMS; CELL-SURVIVAL; IN-VITRO; EFFECTIVENESS RBE; PARTICLE THERAPY; IRRADIATION; RADIOTHERAPY; END; INSTITUTE;
D O I
10.1088/1361-6560/62/3/890
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The purpose of this study is to compare the predictions of the local effect model (LEM) in an extensive analysis to proton relative biological effectiveness (RBE) experiments found in the literature, and demonstrate the capabilities of the model as well as to discuss potential limitations. 19 publications with in vitro experiments and 10 publications with in vivo experiments focusing on proton RBE along the spread out Bragg peak (SOBP) were considered. In total the RBE values of over 100 depth positions were compared to LEM predictions. The treatment planning software TRiP98 was used to reconstruct the proton depth dose profile, and, together with the physical dose distribution, the RBE prediction was conducted based on the LEM. Only parameters from photon dose response curves are used as input for the LEM, and no free parameters are introduced, thus allowing us to demonstrate the predictive power of the LEM for protons. The LEM describes the RBE adequately well within the SOBP region with a relative deviation of typically less than 10% up to 10 keV mu m(-1). In accordance with previous publications a clear dependence of RBE on the dose-averaged linear energy transfer (LETD) was observed. The RBE in the experiments tends to increase above 1.1 for LETD values above 2 keV mu m(-1) and above 1.5 for LETD values higher than 10 keV mu m(-1) (distal part of the SOBP). The dose dependence is most pronounced for doses lower than 3 Gy (RBE). However, both the LEM predictions and experimental data show only a weak dependence of RBE on the tissue type, as characterized by the alpha/beta ratio, which is considered insignificant with regard to the general uncertainties of RBE. The RBE predicted by the LEM shows overall very good agreement with the experimental data within the SOBP region and is in better agreement with the experimental data than the constant RBE of 1.1 that is currently applied in the clinics. All RBE trends deduced from the experiments were also reflected by the LEM predictions, which are purely based on input parameters derived from low-LET photon radiation.
引用
收藏
页码:890 / 908
页数:19
相关论文
共 47 条
[1]   Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East [J].
Ando, K ;
Furusawa, Y ;
Suzuki, M ;
Nojima, K ;
Majima, H ;
Koike, S ;
Aoki, M ;
Shimizu, W ;
Futami, Y ;
Ogino, T ;
Murayama, S ;
Ikeda, H .
JOURNAL OF RADIATION RESEARCH, 2001, 42 (01) :79-89
[2]  
[Anonymous], 2007, J ICRU, V7, DOI DOI 10.1093/JICRU/NDM025
[3]   Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation [J].
Astrahan, Melvin .
MEDICAL PHYSICS, 2008, 35 (09) :4161-4172
[4]  
Bettega D, 2000, INT J RADIAT BIOL, V76, P1297, DOI 10.1080/09553000050151565
[5]   RELATIVE BIOLOGICAL EFFECTIVENESS OF INTERMEDIATE-ENERGY PROTONS - COMPARISONS WITH CO-60 GAMMA-RADIATION USING 2 CELL-LINES [J].
BLOMQUIST, E ;
RUSSELL, KR ;
STENERLOW, B ;
MONTELIUS, A ;
GRUSELL, E ;
CARLSSON, J .
RADIOTHERAPY AND ONCOLOGY, 1993, 28 (01) :44-51
[6]   RADIOBIOLOGICAL CHARACTERIZATION OF TWO THERAPEUTIC PROTON BEAMS WITH DIFFERENT INITIAL ENERGY SPECTRA USED AT THE INSTITUT CURIE PROTON THERAPY CENTER IN ORSAY [J].
Calugaru, Valentin ;
Nauraye, Catherine ;
Noel, Georges ;
Giocanti, Nicole ;
Favaudon, Vincent ;
Megnin-Chanet, Frederique .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 81 (04) :1136-1143
[7]   Range uncertainty in proton therapy due to variable biological effectiveness [J].
Carabe, Alejandro ;
Moteabbed, Maryam ;
Depauw, Nicolas ;
Schuemann, Jan ;
Paganetti, Harald .
PHYSICS IN MEDICINE AND BIOLOGY, 2012, 57 (05) :1159-1172
[8]   Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment [J].
Chaudhary, Pankaj ;
Marshall, Thomas I. ;
Perozziello, Francesca M. ;
Manti, Lorenzo ;
Currell, Frederick J. ;
Hanton, Fiona ;
McMahon, Stephen J. ;
Kavanagh, Joy N. ;
Cirrone, Giuseppe Antonio Pablo ;
Romano, Francesco ;
Prise, Kevin M. ;
Schettino, Giuseppe .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 90 (01) :27-35
[9]   QUANTIFICATION OF THE RELATIVE BIOLOGICAL EFFECTIVENESS FOR ION BEAM RADIOTHERAPY: DIRECT EXPERIMENTAL COMPARISON OF PROTON AND CARBON ION BEAMS AND A NOVEL APPROACH FOR TREATMENT PLANNING [J].
Elsaesser, Thilo ;
Weyrather, Wilma K. ;
Friedrich, Thomas ;
Durante, Marco ;
Iancu, Gheorghe ;
Kraemer, Michael ;
Kragl, Gabriele ;
Brons, Stephan ;
Winter, Marcus ;
Weber, Klaus-Josef ;
Scholz, Michael .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (04) :1177-1183
[10]   Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation [J].
Friedrich, Thomas ;
Scholz, Uwe ;
Elsaesser, Thilo ;
Durante, Marco ;
Scholz, Michael .
JOURNAL OF RADIATION RESEARCH, 2013, 54 (03) :494-514