The evolution of enzyme function in the isomerases

被引：29

作者：

Cuesta, Sergio Martinez ^{[1
]}

Furnham, Nicholas ^{[2
]}

Rahman, Syed Asad ^{[1
]}

Sillitoe, Ian ^{[3
]}

Thornton, Janet M. ^{[1
]}

机构：

[1] European Bioinformat Inst EMB LEBI, European Mol Biol Lab, Cambridge CB10 1SD, England

[2] London Sch Hyg & Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England

[3] UCL, Div Biosci, Inst Struct & Mol Biol, London WC1E 6BT, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 26卷

基金：

英国惠康基金;

关键词：

DIVERGENT EVOLUTION; CATALYTIC PROMISCUITY; CLASSIFICATION; DISCOVERY; SUPERFAMILIES; CONVERGENCE; PLASTICITY; CONVERSION; DIVERSITY; RACEMASE;

D O I：

10.1016/j.sbi.2014.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.

引用

页码：121 / 130

页数：10

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