Myeloid-derived suppressor cells and their role in pancreatic cancer

被引：86
作者：
Pergamo, M. [1 ]
Miller, G. [1 ]
机构：
[1] NYU, Sch Med, S Arthur Localio Lab, Dept Cell Biol, 334 East 26th St,Apt 6H2, New York, NY 10010 USA
来源：
CANCER GENE THERAPY | 2017年 / 24卷 / 03期
关键词：
REGULATORY T-CELLS; TUMOR-ASSOCIATED MACROPHAGE; ANTITUMOR IMMUNITY; PROMOTES; MICROENVIRONMENT; INFLAMMATION; DIFFERENTIATION; GEMCITABINE; SUBSETS; DEATH;
D O I：
10.1038/cgt.2016.65
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pancreatic cancer is a devastating disease and ranks as the third most common cause of cancer-related death: Like many cancers, there has been increased interest in the role of the immune system in the progression and development of pancreatic cancer. In particular, immunosuppression within the tumor microenvironment (TME) is thought to impair the host's antitumor response. In this article, we review myeloid-derived suppressor cells and their contribution to this immunosuppression within the pancreatic TME.
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页码：100 / 105
页数：6
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