The Primordial Thymus: Everything You Need Under One Roof

被引：1

作者：

Anderson, Graham ^{[1
]}

Baik, Song ^{[1
]}

机构：

[1] Univ Birmingham, Ctr Immune Regulat, Sch Immun & Infect, MRC, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNITY | 2014年 / 41卷 / 02期

关键词：

T-CELL DEVELOPMENT; EPITHELIAL-CELLS; SELECTION;

D O I：

10.1016/j.immuni.2014.07.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes normally develop within anatomically distinct tissues. In Cell Reports, Swann et al. (2014) reconstruct the primordial thymus and suggest that it was a site of combined T and B lymphopoiesis before evolving into an organ specialized for T cell production.

引用

收藏

页码：178 / 180

页数：4

相关论文

共 10 条

[1] MHC CLASS-II-POSITIVE EPITHELIUM AND MESENCHYME CELLS ARE BOTH REQUIRED FOR T-CELL DEVELOPMENT IN THE THYMUS [J].

ANDERSON, G ;

JENKINSON, EJ ;

MOORE, NC ;

OWEN, JJT .

NATURE, 1993, 362 (6415) :70-73

[2] Thymic epithelial cells: working class heroes for T cell development and repertoire selection [J].

Anderson, Graham ;

Takahama, Yousuke .

TRENDS IN IMMUNOLOGY, 2012, 33 (06) :256-263

[3] A thymus candidate in lampreys [J].

Bajoghli, Baubak ;

Guo, Peng ;

Aghaallaei, Narges ;

Hirano, Masayuki ;

Strohmeier, Christine ;

McCurley, Nathanael ;

Bockman, Dale E. ;

Schorpp, Michael ;

Cooper, Max D. ;

Boehm, Thomas .

NATURE, 2011, 470 (7332) :90-U101

[4] Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments [J].

Calderon, Lesly ;

Boehm, Thomas .

CELL, 2012, 149 (01) :159-172

[5] FUNCTIONS OF THYMUS SYSTEM AND BURSA SYSTEM IN CHICKEN [J].

COOPER, MD ;

PETERSON, RD ;

SOUTH, MA ;

GOOD, RA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 123 (01) :75-&

[6] Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection [J].

Perera, Jason ;

Meng, Liping ;

Meng, Fanyong ;

Huang, Haochu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (42) :17011-17016

[7] An Overview of the Intrathymic Intricacies of T Cell Development [J].

Shah, Divya K. ;

Zuniga-Pfluecker, Juan Carlos .

JOURNAL OF IMMUNOLOGY, 2014, 192 (09) :4017-4023

[8]

Swann J.B., 2014, CELL REPORTS, V8

[9] Ontogeny and regulation of IL-7-expressing thymic epithelial cells [J].

Zamisch, M ;

Moore-Scott, B ;

Su, D ;

Lucas, PJ ;

Manley, N ;

Richie, ER .

JOURNAL OF IMMUNOLOGY, 2005, 174 (01) :60-67

[10] Trafficking to the Thymus [J].

Zhang, Shirley L. ;

Bhandoola, Avinash .

THYMIC DEVELOPMENT AND SELECTION OF T LYMPHOCYTES, 2014, 373 :87-111