Delivery of epidrugs

被引：19

作者：

el Bahhaj, Fatima ^{[1
]}

Dekker, Frank J. ^{[2
]}

Martinet, Nadine ^{[3
]}

Bertrand, Philippe ^{[1
]}

机构：

[1] CNRS, Inst Chim Milieux & Mat Poitiers, UMR 7582, F-86000 Poitiers, France

[2] Univ Groningen, Groningen Res Inst Pharm, Dept Pharmaceut Gene Modulat, NL-9713 AV Groningen, Netherlands

[3] Inst Chem, UMR CNRS 7272, F-06108 Nice 2, France

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 09期

关键词：

HISTONE DEACETYLASE INHIBITOR; SUBEROYLANILIDE HYDROXAMIC ACID; DNA METHYLTRANSFERASE; IN-VITRO; CANCER-CELLS; 5-AZA-2'-DEOXYCYTIDINE DECITABINE; ACETYLTRANSFERASE INHIBITOR; BIOLOGICAL EVALUATION; NATURAL PRODRUG; DRUG-RESISTANCE;

D O I：

10.1016/j.drudis.2014.03.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inhibitors of epigenetic targets have entered clinical trials with some success, in particular for combined therapies. Like many other chemotherapeutics these new classes of molecules have dose-limiting toxicities and highly active metabolism in vivo resulting in lower efficacy than expected. This review presents drug delivery strategies proposed to prolong epigenetic inhibitor effects while reducing toxicities and metabolic clearance. Inspired from the work done in cancer-targeted strategies, prodrugs and nanoparticle-based drug delivery systems are discussed in a comprehensive way, detailing the chemical and physiological principles of the selected releasing method and, when available, how epigenetic chemistry can be exploited.

引用

页码：1337 / 1352

页数：16

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